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Thomas Isbrandt

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Citations 112
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Recent Articles
1.
Bjork P, Johansen N, Havshoi N, Rasmussen S, Ipsen J, Isbrandt T, et al.
ACS Omega . 2023 Oct; 8(38):34928-34937. PMID: 37779967
Because of their ability to promote growth, act as biopesticides, and improve abiotic stress tolerance, spp. have been used for plant seed coating. However, the mechanism for the promotion of...
2.
Zhang S, Lindqvist L, Isbrandt T, Borre I, Wibowo M, Nielsen M, et al.
Appl Environ Microbiol . 2022 Aug; 88(17):e0110522. PMID: 36000852
The marine bacterium Photobacterium galatheae S2753 produces a group of cyclodepsipeptides, called solonamides, which impede the virulence but not the survival of Staphylococcus aureus. In addition to their invaluable antivirulence...
3.
Christiansen J, Isbrandt T, Asferg R, Jarmusch S, Ostenfeld Larsen T, Frisvad J
Appl Environ Microbiol . 2022 Jun; 88(12):e0030222. PMID: 35670582
Society faces the challenge of storing energy from sustainable sources in inexpensive, nontoxic ways that do not deplete the limited resources of Earth. In this regard, quinone redox flow batteries...
4.
Wang X, Isbrandt T, Christensen E, Melchiorsen J, Ostenfeld Larsen T, Zhang S, et al.
Microbiol Spectr . 2021 Nov; 9(2):e0117121. PMID: 34724731
Pseudoalteromonas rubra S4059 produces the red pigment prodigiosin, which has pharmaceutical and industrial potential. Here, we targeted a putative prodigiosin-synthesizing transferase PigC, and a in-frame deletion mutant did not produce...
5.
Zhang S, Isbrandt T, Lindqvist L, Ostenfeld Larsen T, Gram L
Appl Environ Microbiol . 2021 Mar; 87(11). PMID: 33771780
While the effects of antibiotics on microorganisms are widely studied, it remains less well understood how antibiotics affect the physiology of the native producing organisms. Here, using a marine bacterium,...
6.
Buijs Y, Zhang S, Jorgensen K, Isbrandt T, Ostenfeld Larsen T, Gram L
FEMS Microbiol Ecol . 2021 Mar; 97(4). PMID: 33693627
Deciphering the cues that stimulate microorganisms to produce their full secondary metabolic potential promises to speed up the discovery of novel drugs. Ecology-relevant conditions, including carbon-source(s) and microbial interactions, are...
7.
Wang X, Isbrandt T, Strube M, Paulsen S, Nielsen M, Buijs Y, et al.
Mar Drugs . 2021 Mar; 19(2). PMID: 33673118
Genome mining of pigmented has revealed a large potential for the production of bioactive compounds and hydrolytic enzymes. The purpose of the present study was to explore this bioactivity potential...
8.
Subko K, Wang X, Nielsen F, Isbrandt T, Gotfredsen C, Ramos M, et al.
Front Microbiol . 2021 Feb; 11:618730. PMID: 33519780
Asperphenamate is a small peptide natural product that has gained much interest due to its antitumor activity. In the recent years numerous bioactive synthetic asperphenamate analogs have been reported, whereas...
9.
Buijs Y, Isbrandt T, Zhang S, Ostenfeld Larsen T, Gram L
Front Microbiol . 2021 Jan; 11:622055. PMID: 33424823
The development and spread of multidrug resistant pathogens have reinforced the urgency to find novel natural products with antibiotic activity. In bacteria, orphan biosynthetic gene clusters (BGCs) far outnumber the...
10.
Paulsen S, Isbrandt T, Kirkegaard M, Buijs Y, Strube M, Sonnenschein E, et al.
Sci Rep . 2020 Dec; 10(1):21630. PMID: 33303891
Novel antimicrobials are urgently needed due to the rapid spread of antibiotic resistant bacteria. In a genome-wide analysis of Pseudoalteromonas strains, one strain (S4498) was noticed due to its potent...