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Thomas Hellmark

Explore the profile of Thomas Hellmark including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 62
Citations 1106
Followers 0
Related Specialties
Nephrology
Allergy & Immunology
Rheumatology
Top 10 Co-Authors
Marten Segelmark
Asa Pettersson
Jorgen Wieslander
Markus Hansson
Sophie Ohlsson
Anders A Bengtsson
Ming-Hui Zhao
Asa C M Johansson
Zhao Cui
Asa Johansson
Published In
J Immunol Res
Nephrol Dial Transplant
J Am Soc Nephrol
Am J Kidney Dis
J Biol Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Decreased neutrophil function in newly diagnosed multiple myeloma patients is restored with lenalidomide therapy
Askman S, Westerlund J, Pettersson A, Hellmark T, Johansson A, Wichert S, et al.
Eur J Haematol . 2024 Mar; 113(1):72-81. PMID: 38553844
Objectives: Bacterial infections are common and a major cause of morbidity and mortality in multiple myeloma (MM). We have investigated the function of polymorphonuclear leukocyte (PMN), the immune system's first...
2.
Disease Activity and Tendency to Relapse in ANCA-Associated Vasculitis Are Reflected in Neutrophil and Intermediate Monocyte Frequencies
Smargianaki S, Elmer E, Lilliebladh S, Ohlsson S, Pettersson A, Hellmark T, et al.
J Immunol Res . 2024 Jan; 2024:6648265. PMID: 38213873
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune diseases with inflammation affecting small blood vessels and includes granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). In this...
3.
Atypical Anti-Glomerular Basement Membrane Nephritis: A Case Series From the French Nephropathology Group
Chauveau B, Gibier J, Olagne J, Morel A, Aydin S, McAdoo S, et al.
Am J Kidney Dis . 2024 Jan; 83(6):713-728.e1. PMID: 38171412
Rationale & Objective: Atypical anti-glomerular basement membrane (GBM) nephritis is characterized by a bright linear immunoglobulin staining along the GBM by immunofluorescence without a diffuse crescentic glomerulonephritis nor serum anti-GBM...
4.
Causes of nephrotic syndrome in Sweden: The relevance of clinical presentation and demographics
Jonsson A, Hellmark T, Segelmark M, Forsberg A, Dreja K
Front Nephrol . 2023 Sep; 3:1026864. PMID: 37675382
Background: Many pathological processes can disrupt the integrity of the glomerular capillary wall and cause a massive leakage of protein, resulting in nephrotic syndrome (NS). Clinical parameters such as age,...
5.
Using imlifidase to elucidate the characteristics and importance of anti-GBM antibodies produced after start of treatment
Tyrberg L, Andersson F, Uhlin F, Hellmark T, Segelmark M
Nephrol Dial Transplant . 2023 Jun; 39(1):45-54. PMID: 37385828
Background: Autoantibodies are common in glomerulonephritis, but the clinical benefit of rapid elimination has not been determined, even in anti-glomerular basement membrane (GBM) disease. Even less is known about the...
6.
Regulatory B cells are reduced in the blood in patients with granulomatosis with polyangiitis, and fail to regulate T-cell IFN-γ production
Appelgren D, Puli S, Hellmark T, Pochard P, Pers J, Ernerudh J, et al.
Clin Exp Immunol . 2023 Feb; 213(2):190-201. PMID: 36752779
Regulatory B (Breg) cells can dampen inflammation, autoreactivity, and transplant rejection. We investigated the frequencies, phenotypes, and function of Breg cells in granulomatosis with polyangiitis (GPA) to gain further knowledge...
7.
A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune function
Bahnan W, Happonen L, Khakzad H, Kumra Ahnlide V, de Neergaard T, Wrighton S, et al.
EMBO Mol Med . 2022 Dec; 15(2):e16208. PMID: 36507602
Group A streptococci have evolved multiple strategies to evade human antibodies, making it challenging to create effective vaccines or antibody treatments. Here, we have generated antibodies derived from the memory...
8.
Suppression of T-Cell Proliferation by Normal Density Granulocytes Led to CD183 Downregulation and Cytokine Inhibition in T-Cells
Westerlund J, Askman S, Pettersson A, Hellmark T, Johansson A, Hansson M
J Immunol Res . 2022 Nov; 2022:8077281. PMID: 36438199
Normal density granulocytes (NDGs) can suppress T-cell responses in a similar way as myeloid-derived suppressor cells (MDSCs). In this study, we tested the hypothesis that NDGs from healthy donors preferentially...
9.
Methotrexate Treatment Suppresses Monocytes in Nonresponders to Pneumococcal Conjugate Vaccine in Rheumatoid Arthritis Patients
Elmer E, Nived P, Pettersson A, Skattum L, Hellmark T, Kapetanovic M, et al.
J Immunol Res . 2022 Aug; 2022:7561661. PMID: 35935581
Patients with rheumatoid arthritis (RA) have an increased risk of infections; therefore, immunization against vaccine-preventable diseases is important. Methotrexate (MTX) impairs the antibody response to pneumococcal conjugate vaccine (PCV) in...
10.
Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2
Bahnan W, Wrighton S, Sundwall M, Blackberg A, Larsson O, Hoglund U, et al.
Front Immunol . 2022 Jan; 12:808932. PMID: 35095897
Spike-specific antibodies are central to effective COVID19 immunity. Research efforts have focused on antibodies that neutralize the ACE2-Spike interaction but not on non-neutralizing antibodies. Antibody-dependent phagocytosis is an immune mechanism...