Thomas H Sisson
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Explore the profile of Thomas H Sisson including associated specialties, affiliations and a list of published articles.
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2417
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Recent Articles
1.
Sisson T, Osterholzer J, Leung L, Basrur V, Nesvizhskii A, Subbotina N, et al.
bioRxiv
. 2024 Aug;
PMID: 39211273
Plasminogen activator inhibitor-1 (PAI-1) has been previously shown to promote lung fibrosis via a mechanism that requires an intact vitronectin (VTN) binding site. In the present study, employing two distinct...
2.
Cooper J, Lathuiliere A, Su E, Song Y, Torrente D, Jo Y, et al.
J Biol Chem
. 2024 Apr;
300(6):107313.
PMID: 38657864
Sortilin-related receptor 1 (SORL1) is an intracellular sorting receptor genetically implicated in Alzheimer's disease (AD) that impacts amyloid precursor protein trafficking. The objective of these studies was to test the...
3.
Kwak D, Bradley P, Subbotina N, Ling S, Teitz-Tennenbaum S, Osterholzer J, et al.
Respir Res
. 2023 Dec;
24(1):314.
PMID: 38098035
Recent data from human studies and animal models have established roles for type II alveolar epithelial cell (AEC2) injury/apoptosis and monocyte/macrophage accumulation and activation in progressive lung fibrosis. Although the...
4.
Frame D, Scappaticci G, Braun T, Maliarik M, Sisson T, Pipe S, et al.
Chest
. 2022 Apr;
162(2):346-355.
PMID: 35413279
Background: SARS-CoV-2-related ARDS is associated with endothelial dysfunction and profound dysregulation of the thrombotic-fibrinolytic pathway. Defibrotide is a polyanionic compound with fibrinolytic, antithrombotic, and antiinflammatory properties. Research Question: What is...
5.
Teitz-Tennenbaum S, Viglianti S, Jomma A, Palone Q, Andrews H, Selbmann K, et al.
Am J Pathol
. 2021 Dec;
192(3):410-425.
PMID: 34954211
Histopathologic evidence of deployment-related constrictive bronchiolitis (DRCB) has been identified in soldiers deployed to Southwest Asia. While inhalational injury to the airway epithelium is suspected, relatively little is known about...
6.
Yang J, Agarwal M, Ling S, Teitz-Tennenbaum S, Zemans R, Osterholzer J, et al.
Am J Respir Cell Mol Biol
. 2020 Jan;
62(5):622-632.
PMID: 31922885
Accumulating evidence suggests that fibrosis is a multicellular process with contributions from alveolar epithelial cells (AECs), recruited monocytes/macrophages, and fibroblasts. We have previously shown that AEC injury is sufficient to...
7.
Horowitz J, Tschumperlin D, Kim K, Osterholzer J, Subbotina N, Ajayi I, et al.
Thromb Haemost
. 2019 Nov;
119(12):1968-1980.
PMID: 31705517
Introduction: Impaired plasminogen activation (PA) is causally related to the development of lung fibrosis. Prior studies demonstrate that enhanced PA in the lung limits the severity of scarring following injury...
8.
Kim K, Dotson M, Agarwal M, Yang J, Bradley P, Subbotina N, et al.
Cell Death Dis
. 2018 Oct;
9(11):1056.
PMID: 30333529
Type II alveolar epithelial cell (AEC) apoptosis is a prominent feature of fibrotic lung diseases and animal models of pulmonary fibrosis. While there is growing recognition of the importance of...
9.
Sisson T, Christensen P, Muraki Y, Dils A, Chibucos L, Subbotina N, et al.
Physiol Rep
. 2018 Jun;
6(12):e13753.
PMID: 29952109
Fibrosis of the lung constitutes a major clinical challenge and novel therapies are required to alleviate the associated morbidity and mortality. Investigating the antifibrotic efficacy of drugs that are already...
10.
Dodi A, Ajayi I, Chang C, Beard M, Ashley S, Huang S, et al.
Respir Res
. 2018 May;
19(1):91.
PMID: 29747634
Background: Fibroblast apoptosis is a critical component of normal repair and the acquisition of an apoptosis-resistant phenotype contributes to the pathogenesis of fibrotic repair. Fibroblasts from fibrotic lungs of humans...