Thomas H Sharp
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Explore the profile of Thomas H Sharp including associated specialties, affiliations and a list of published articles.
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44
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916
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Recent Articles
1.
Last M, Abendstein L, Voortman L, Sharp T
Elife
. 2024 Dec;
13.
PMID: 39704648
Segmentation is a critical data processing step in many applications of cryo-electron tomography. Downstream analyses, such as subtomogram averaging, are often based on segmentation results, and are thus critically dependent...
2.
Schubert S, Ruano D, Joruiz S, Stroosma J, Glavak N, Montali A, et al.
Nat Commun
. 2024 Sep;
15(1):8208.
PMID: 39294166
Germline and somatic TP53 variants play a crucial role during tumorigenesis. However, genetic variations that solely affect the alternatively spliced p53 isoforms, p53β and p53γ, are not fully considered in...
3.
Noone D, Isendoorn M, Hamers S, Keizer M, Wulffele J, van der Velden T, et al.
Proc Natl Acad Sci U S A
. 2024 Sep;
121(37):e2404542121.
PMID: 39240968
Human C-reactive protein (CRP) is a pentameric complex involved in immune defense and regulation of autoimmunity. CRP is also a therapeutic target, with both administration and depletion of serum CRP...
4.
Hamers S, Abendstein L, Boyle A, Jongkees S, Sharp T
RSC Chem Biol
. 2024 Aug;
5(8):787-799.
PMID: 39092440
The human complement pathway plays a pivotal role in immune defence, homeostasis, and autoimmunity regulation, and complement-based therapeutics have emerged as promising interventions, with both antagonistic and agonistic approaches being...
5.
Hamers S, Boyle A, Sharp T
J Immunol
. 2024 May;
213(2):235-243.
PMID: 38819221
The development of agonists capable of activating the human complement system by binding to the C1 complex presents a novel approach for targeted cell killing. Bispecific nanobodies and Abs can...
6.
Wang H, van de Bovenkamp F, Dijkstra D, Abendstein L, Borggreven N, Pool J, et al.
Front Immunol
. 2024 May;
15:1288597.
PMID: 38817607
Complement activation protects against infection but also contributes to pathological mechanisms in a range of clinical conditions such as autoimmune diseases and transplant rejection. Complement-inhibitory drugs, either approved or in...
7.
Aba G, Scheeren F, Sharp T
Methods Mol Biol
. 2024 May;
2800:35-53.
PMID: 38709476
Clustering of type II tumor necrosis factor (TNF) receptors (TNFRs) is essential for their activation, yet currently available drugs fail to activate signaling. Some strategies aim to cluster TNFR by...
8.
Last M, Voortman L, Sharp T
Methods Cell Biol
. 2024 May;
187:223-248.
PMID: 38705626
Super-resolution cryo-correlative light and electron microscopy (SRcryoCLEM) is emerging as a powerful method to enable targeted in situ structural studies of biological samples. By combining the high specificity and localization...
9.
Last M, Voortman L, Sharp T
Methods Cell Biol
. 2024 May;
187:205-222.
PMID: 38705625
Correlated super-resolution fluorescence microscopy and cryo-electron microscopy enables imaging with both high labeling specificity and high resolution. Naturally, combining two sophisticated imaging techniques within one workflow also introduces new requirements...
10.
Abendstein L, Noteborn W, Veenman L, Dijkstra D, van de Bovenkamp F, Trouw L, et al.
J Am Chem Soc
. 2024 May;
146(19):13455-13466.
PMID: 38703132
The classical complement pathway is activated by antigen-bound IgG antibodies. Monomeric IgG must oligomerize to activate complement via the hexameric C1q complex, and hexamerizing mutants of IgG appear as promising...