Thomas Grundstrom
Overview
Explore the profile of Thomas Grundstrom including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
360
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Recent Articles
1.
Grundstrom C, Grundstrom T
Mol Immunol
. 2022 Nov;
153:51-59.
PMID: 36434987
Class switch recombination (CSR) changes the constant region of the immunoglobulin heavy chain (IgH), and somatic hypermutation (SH) introduces point mutations in the variable regions of the antibody genes. Both...
2.
Wang T, Sarwar M, Whitchurch J, Collins H, Green T, Semenas J, et al.
Front Cell Dev Biol
. 2022 Apr;
10:798590.
PMID: 35386201
PIP5K1α has emerged as a promising drug target for the treatment of castration-resistant prostate cancer (CRPC), as it acts upstream of the PI3K/AKT signaling pathway to promote prostate cancer (PCa)...
3.
Larsson P, Karlsson R, Sarwar M, Miftakhova R, Wang T, Syed Khaja A, et al.
Mol Oncol
. 2021 Dec;
16(13):2496-2517.
PMID: 34932854
Low-affinity immunoglobulin gamma Fc region receptor III-A (FcγRIIIa) is a cell surface protein that belongs to a family of Fc receptors that facilitate the protective function of the immune system...
4.
Semenas J, Wang T, Syed Khaja A, Mahmud A, Simoulis A, Grundstrom T, et al.
Mol Oncol
. 2020 Dec;
15(4):968-986.
PMID: 33275817
Selective ERα modulator, tamoxifen, is well tolerated in a heavily pretreated castration-resistant prostate cancer (PCa) patient cohort. However, its targeted gene network and whether expression of intratumor ERα due to...
5.
Karlsson R, Larsson P, Miftakhova R, Syed Khaja A, Sarwar M, Semenas J, et al.
Cancers (Basel)
. 2020 Sep;
12(9).
PMID: 32971916
Cancer cells facilitate growth and metastasis by using multiple signals from the cancer-associated microenvironment. However, it remains poorly understood whether prostate cancer (PCa) cells may recruit and utilize bone marrow...
6.
Kumar A, Priya A, Ahmed T, Grundstrom C, Negi N, Grundstrom T
J Immunol
. 2018 Oct;
201(11):3472-3473.
PMID: 30373847
No abstract available.
7.
Grundstrom C, Kumar A, Priya A, Negi N, Grundstrom T
Eur J Immunol
. 2018 Aug;
48(10):1687-1697.
PMID: 30089192
B lymphocytes optimize antibody responses by class switch recombination (CSR), which changes the expressed constant region exon of the immunoglobulin heavy chain (IgH), and by somatic hypermutation (SH) that introduces...
8.
Kumar A, Priya A, Ahmed T, Grundstrom C, Negi N, Grundstrom T
J Immunol
. 2018 May;
200(12):4146-4156.
PMID: 29728513
B lymphocytes optimize Ab responses by somatic hypermutation (SH), which introduces point mutations in the variable regions of the Ab genes and by class-switch recombination (CSR), which changes the expressed...
9.
Hauser J, Grundstrom C, Kumar R, Grundstrom T
Mol Immunol
. 2016 Nov;
80:78-90.
PMID: 27835756
Activation-induced cytidine deaminase (AID) is the key mutagenic enzyme that initiates somatic hypermutation (SH) and class switch recombination (CSR) by deaminating cytosine to uracil. The targeting of AID and therefore...
10.
Wallenius A, Hauser J, Aas P, Sarno A, Kavli B, Krokan H, et al.
Mol Immunol
. 2014 Apr;
60(1):23-31.
PMID: 24747958
B-lymphocytes can modify their immunoglobulin (Ig) genes to generate specific antibodies with a new isotype and enhanced affinity against an antigen. Activation-induced cytidine deaminase (AID), which is positively regulated by...