Thomas Gentinetta
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Explore the profile of Thomas Gentinetta including associated specialties, affiliations and a list of published articles.
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15
Citations
272
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Recent Articles
1.
Lucero M, Lucero M, Lisk C, Cendali F, Swindle D, Setua S, et al.
Free Radic Biol Med
. 2025 Jan;
229:458-473.
PMID: 39862998
Lung tissue from human patients and murine models of sickle cell disease pulmonary hypertension (SCD-PH) show perivascular regions with excessive iron accumulation. The iron accumulation arises from chronic hemolysis and...
2.
Mueller E, Rahimi S, Sauta P, Shojaeian T, Durrer L, Quinche S, et al.
Curr Protoc
. 2024 Aug;
4(8):e1118.
PMID: 39169810
Antibody-mediated receptor activation is successfully used to develop medical treatments. If the activation induces a pathological response, such antibodies are also excellent tools for defining molecular mechanisms of target receptor...
3.
Thomson B, Schwendinger N, Beckmann K, Gentinetta T, Couto D, Wymann S, et al.
Transl Stroke Res
. 2024 Apr;
PMID: 38652234
Secondary brain injury (SBI) occurs with a lag of several days post-bleeding in patients with aneurysmal subarachnoid hemorrhage (aSAH) and is a strong contributor to mortality and long-term morbidity. aSAH-SBI...
4.
Gentinetta T, Belcher J, Brugger-Verdon V, Adam J, Ruthsatz T, Bain J, et al.
J Clin Med
. 2022 Feb;
11(3).
PMID: 35160081
People living with sickle cell disease (SCD) face intermittent acute pain episodes due to vaso-occlusion primarily treated palliatively with opioids. Hemolysis of sickle erythrocytes promotes release of heme, which activates...
5.
Vallelian F, Buzzi R, Pfefferle M, Yalamanoglu A, Dubach I, Wassmer A, et al.
Cell Death Differ
. 2022 Jan;
29(8):1450-1465.
PMID: 35031770
Heme is an erythrocyte-derived toxin that drives disease progression in hemolytic anemias, such as sickle cell disease. During hemolysis, specialized bone marrow-derived macrophages with a high heme-metabolism capacity orchestrate disease...
6.
Buehler P, Swindle D, Pak D, Ferguson S, Majka S, Karoor V, et al.
Free Radic Biol Med
. 2021 Sep;
175:95-107.
PMID: 34478834
Hemopexin (Hpx) is a crucial defense protein against heme liberated from degraded hemoglobin during hemolysis. High heme stress creates an imbalance in Hpx bioavailability, favoring heme accumulation and downstream pathophysiological...
7.
Buzzi R, Owczarek C, Akeret K, Tester A, Pereira N, Butcher R, et al.
Mol Pharm
. 2021 Jul;
18(8):3158-3170.
PMID: 34292741
Cell-free hemoglobin (Hb) is a driver of disease progression in conditions with intravascular or localized hemolysis. Genetic and acquired anemias or emergency medical conditions such as aneurysmal subarachnoid hemorrhage involve...
8.
Haptoglobin treatment prevents cell-free hemoglobin exacerbated mortality in experimental rat sepsis
Schaer C, Jeger V, Gentinetta T, Spahn D, Vallelian F, Rudiger A, et al.
Intensive Care Med Exp
. 2021 May;
9(1):22.
PMID: 33937959
No abstract available.
9.
Agyemang A, Kvist S, Brinkman N, Gentinetta T, Illa M, Ortenlof N, et al.
J Neuroinflammation
. 2021 Feb;
18(1):42.
PMID: 33573677
Background: Germinal matrix intraventricular hemorrhage (GM-IVH) is associated with deposition of redox active cell-free hemoglobin (Hb), derived from hemorrhagic cerebrospinal fluid (CSF), in the cerebrum and cerebellum. In a recent...
10.
Poillerat V, Gentinetta T, Leon J, Wassmer A, Edler M, Torset C, et al.
Front Immunol
. 2020 Aug;
11:1684.
PMID: 32849588
Hemopexin is the main plasmatic scavenger of cell-free heme, released in the context of intravascular hemolysis or major cell injury. Heme is indispensable for the oxygen transport by hemoglobin but...