Thomas F Westbrook
Overview
Explore the profile of Thomas F Westbrook including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
54
Citations
5909
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Henke D, Renwick A, Zoeller J, Meena J, Neill N, Bowling E, et al.
NPJ Precis Oncol
. 2025 Feb;
9(1):39.
PMID: 39915634
Precision medicine relies on identifying reliable biomarkers for gene dependencies to tailor individualized therapeutic strategies. The advent of high-throughput technologies presents unprecedented opportunities to explore molecular disease mechanisms but also...
2.
Xu L, Peng F, Luo Q, Ding Y, Yuan F, Zheng L, et al.
Cell
. 2024 Oct;
187(25):7248-7266.e34.
PMID: 39419025
Chemotherapy is often combined with immune checkpoint inhibitor (ICIs) to enhance immunotherapy responses. Despite the approval of chemo-immunotherapy in multiple human cancers, many immunologically cold tumors remain unresponsive. The mechanisms...
3.
Meena J, Wang J, Neill N, Keough D, Putluri N, Katsonis P, et al.
Cancer Discov
. 2024 Aug;
14(9):1699-1716.
PMID: 39193992
Upregulation of MYC is a hallmark of cancer, wherein MYC drives oncogenic gene expression and elevates total RNA synthesis across cancer cell transcriptomes. Although this transcriptional anabolism fuels cancer growth...
4.
Bouguenina H, Nicolaou S, Le Bihan Y, Bowling E, Calderon C, Caldwell J, et al.
iScience
. 2024 Apr;
27(5):109727.
PMID: 38646177
[This corrects the article DOI: 10.1016/j.isci.2023.107059.].
5.
Bouguenina H, Nicolaou S, Le Bihan Y, Bowling E, Calderon C, Caldwell J, et al.
iScience
. 2023 Jun;
26(7):107059.
PMID: 37360684
To address the limitation associated with degron based systems, we have developed iTAG, a synthetic tag based on IMiDs/CELMoDs mechanism of action that improves and addresses the limitations of both...
6.
Ramabadran R, Wang J, Reyes J, Guzman A, Gupta S, Rosas C, et al.
Nat Cell Biol
. 2023 Apr;
25(4):528-539.
PMID: 37024683
Upon stimulation by extrinsic stimuli, stem cells initiate a programme that enables differentiation or self-renewal. Disruption of the stem state exit has catastrophic consequences for embryogenesis and can lead to...
7.
Cai W, Chen J, Chen H, Wingrove E, Kurley S, Chan L, et al.
Elife
. 2022 Aug;
11.
PMID: 36043466
Metastatic breast cancer remains a major cause of cancer-related deaths in women, and there are few effective therapies against this advanced disease. Emerging evidence suggests that key steps of tumor...
8.
Gao Y, Kabotyanski E, Shepherd J, Villegas E, Acosta D, Hamor C, et al.
Cancer Res Commun
. 2022 Feb;
1(3):178-193.
PMID: 35156101
Polo-like kinase (PLK) family members play important roles in cell cycle regulation. The founding member PLK1 is oncogenic and preclinically validated as a cancer therapeutic target. Paradoxically, frequent loss of...
9.
Einstein J, Perelis M, Chaim I, Meena J, Nussbacher J, Tankka A, et al.
Mol Cell
. 2021 Jul;
81(15):3048-3064.e9.
PMID: 34216543
RNA-binding proteins (RBPs) are critical regulators of post-transcriptional gene expression, and aberrant RBP-RNA interactions can promote cancer progression. Here, we interrogate the function of RBPs in cancer using pooled CRISPR-Cas9...
10.
Arabzade A, Zhao Y, Varadharajan S, Chen H, Jessa S, Rivas B, et al.
Cancer Discov
. 2021 Mar;
11(9):2200-2215.
PMID: 33741710
More than 60% of supratentorial ependymomas harbor a (ZR) gene fusion (formerly ). To study the biology of ZR, we developed an autochthonous mouse tumor model using electroporation (IUE) of...