Thomas Desplantez
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Explore the profile of Thomas Desplantez including associated specialties, affiliations and a list of published articles.
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16
Citations
363
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Recent Articles
1.
Boyle P, Franceschi W, Constantin M, Hawks C, Desplantez T, Trayanova N, et al.
J Mol Cell Cardiol
. 2019 Jan;
128:117-128.
PMID: 30677394
Cardiac conduction disturbances are linked with arrhythmia development. The concept of safety factor (SF) has been derived to describe the robustness of conduction, but the usefulness of this metric has...
2.
Desplantez T
BMC Cell Biol
. 2017 Jan;
18(Suppl 1):3.
PMID: 28124623
Background: This review comes after the International Gap Junction Conference (IGJC 2015) and describes the current knowledge on the function of the specific motifs of connexins in the regulation of...
3.
Thomas N, Gray R, Fry C, Desplantez T, Peters N, Severs N, et al.
Biochem Biophys Res Commun
. 2016 Dec;
483(1):191-196.
PMID: 28034749
The functional characteristics of the co-expression of connexin43, connexin40, and connexin45 proteins in human myocardium are thought to play an important role in governing normal propagation of the cardiac electrical...
4.
McCain M, Desplantez T, Kleber A
Cell Commun Adhes
. 2014 Apr;
21(3):181-91.
PMID: 24754499
This review article discusses a recent work using engineered cardiac cells to study the function of the intercalated disc putting emphasis on mechanical and electrical coupling.
5.
Dias P, Desplantez T, El-Harasis M, Chowdhury R, Ullrich N, Cabestrero de Diego A, et al.
PLoS One
. 2014 Mar;
9(2):e90266.
PMID: 24587307
The HL-1 atrial line contains cells blocked at various developmental stages. To obtain homogeneous sub-clones and correlate changes in gene expression with functional alterations, individual clones were obtained and characterised...
6.
Beauchamp P, Desplantez T, McCain M, Li W, Asimaki A, Rigoli G, et al.
Circ Res
. 2012 Apr;
110(11):1445-53.
PMID: 22518032
Rationale: Spatial heterogeneity in connexin (Cx) expression has been implicated in arrhythmogenesis. Objective: This study was performed to quantify the relation between the degree of heterogeneity in Cx43 expression and...
7.
Desplantez T, McCain M, Beauchamp P, Rigoli G, Rothen-Rutishauser B, Parker K, et al.
Cardiovasc Res
. 2012 Jan;
94(1):58-65.
PMID: 22287588
Aims: Remodelling and regional gradients in expression of connexins (Cx) are thought to contribute to atrial electrical dysfunction and atrial fibrillation. We assessed the effect of interaction between Cx43, Cx40,...
8.
McCain M, Desplantez T, Geisse N, Rothen-Rutishauser B, Oberer H, Parker K, et al.
Am J Physiol Heart Circ Physiol
. 2011 Nov;
302(2):H443-50.
PMID: 22081700
Gap junctions are composed of connexin (Cx) proteins, which mediate intercellular communication. Cx43 is the dominant Cx in ventricular myocardium, and Cx45 is present in trace amounts. Cx43 immunosignal has...
9.
Desplantez T, Halliday D, Dupont E, Severs N, Weingart R
J Membr Biol
. 2011 Mar;
240(3):139-50.
PMID: 21424225
HeLa cells expressing wild-type connexin43, connexin40 or connexin45 and connexins fused with a V5/6-His tag to the carboxyl terminus (CT) domain (Cx43-tag, Cx40-tag, Cx45-tag) were used to study connexin expression...
10.
Derouette J, Desplantez T, Wong C, Roth I, Kwak B, Weingart R
J Mol Cell Cardiol
. 2009 Jan;
46(4):499-507.
PMID: 19166859
A polymorphism in the human Cx37 gene (C1019T), resulting in a non-conservative amino acid change in the regulatory C-terminus of the Cx37 protein (P319S), has been proposed as a prognostic...