Nicholas J Severs
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Explore the profile of Nicholas J Severs including associated specialties, affiliations and a list of published articles.
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54
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Recent Articles
1.
Thomas N, Gray R, Fry C, Desplantez T, Peters N, Severs N, et al.
Biochem Biophys Res Commun
. 2016 Dec;
483(1):191-196.
PMID: 28034749
The functional characteristics of the co-expression of connexin43, connexin40, and connexin45 proteins in human myocardium are thought to play an important role in governing normal propagation of the cardiac electrical...
2.
Dias P, Desplantez T, El-Harasis M, Chowdhury R, Ullrich N, Cabestrero de Diego A, et al.
PLoS One
. 2014 Mar;
9(2):e90266.
PMID: 24587307
The HL-1 atrial line contains cells blocked at various developmental stages. To obtain homogeneous sub-clones and correlate changes in gene expression with functional alterations, individual clones were obtained and characterised...
3.
Facer P, Punjabi P, Abrari A, Kaba R, Severs N, Chambers J, et al.
Int Heart J
. 2011 Jun;
52(3):146-52.
PMID: 21646736
We have shown that the gene SCN10A encoding the sodium channel Na(v)1.8 is a susceptibility factor for heart block and serious ventricular arrhythmia. Since Na(v)1.8 is known to be present...
4.
Hofnagel O, Engel T, Severs N, Robenek H, Buers I
Atherosclerosis
. 2011 May;
217(2):371-8.
PMID: 21612780
Objective: The scavenger receptor SR-PSOX/CXCL16, which is identical to the chemokine CXCL16, is thought to be involved in atherogenesis. However, the presence and function of SR-PSOX/CXCL16 in the endothelium of...
5.
Robenek H, Buers I, Robenek M, Hofnagel O, Ruebel A, Troyer D, et al.
J Lipids
. 2011 Apr;
2011:409371.
PMID: 21490801
Lipid droplets are not merely storage depots for superfluous intracellular lipids in times of hyperlipidemic stress, but metabolically active organelles involved in cellular homeostasis. Our concepts on the metabolic functions...
6.
Buers I, Hofnagel O, Ruebel A, Severs N, Robenek H
Histol Histopathol
. 2011 Mar;
26(5):631-42.
PMID: 21432779
Coronary heart disease and stroke, caused by rupture of atherosclerotic plaques in the arterial wall, are the major causes of death in industrialized countries. A key event in the pathogenesis...
7.
Desplantez T, Halliday D, Dupont E, Severs N, Weingart R
J Membr Biol
. 2011 Mar;
240(3):139-50.
PMID: 21424225
HeLa cells expressing wild-type connexin43, connexin40 or connexin45 and connexins fused with a V5/6-His tag to the carboxyl terminus (CT) domain (Cx43-tag, Cx40-tag, Cx45-tag) were used to study connexin expression...
8.
Schuster M, Kilaru S, Ashwin P, Lin C, Severs N, Steinberg G
EMBO J
. 2011 Feb;
30(4):652-64.
PMID: 21278707
Bidirectional transport of early endosomes (EEs) involves microtubules (MTs) and associated motors. In fungi, the dynein/dynactin motor complex concentrates in a comet-like accumulation at MT plus-ends to receive kinesin-3-delivered EEs...
9.
Chambers J, Zhao J, Terracciano C, Bezzina C, Zhang W, Kaba R, et al.
Nat Genet
. 2010 Jan;
42(2):149-52.
PMID: 20062061
To identify genetic factors influencing cardiac conduction, we carried out a genome-wide association study of electrocardiographic time intervals in 6,543 Indian Asians. We identified association of a nonsynonymous SNP, rs6795970,...
10.
Robenek H, Severs N
J Cell Mol Med
. 2009 Oct;
13(11-12):4657-61.
PMID: 19863694
An understanding of how lipid droplets grow in the cell is important to current human health issues. Homotypic fusion of small lipid droplets to create larger ones is one proposed...