Thomas D Willis
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Explore the profile of Thomas D Willis including associated specialties, affiliations and a list of published articles.
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13
Citations
4317
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Recent Articles
1.
Roschewski M, Dunleavy K, Pittaluga S, Moorhead M, Pepin F, Kong K, et al.
Lancet Oncol
. 2015 Apr;
16(5):541-9.
PMID: 25842160
Background: Diffuse large-B-cell lymphoma is curable, but when treatment fails, outcome is poor. Although imaging can help to identify patients at risk of treatment failure, they are often imprecise, and...
2.
Bentivegna S, Zheng J, Namsaraev E, Carlton V, Pavlicek A, Moorhead M, et al.
Hum Mutat
. 2008 Jan;
29(3):441-50.
PMID: 18186519
Mismatch repair detection (MRD) was used to screen 93 matched tumor-normal sample pairs and 22 cell lines for somatic mutations in 30 cancer relevant genes. Using a starting amount of...
3.
Sabeti P, Fry B, Lohmueller J, Hostetter E, Cotsapas C, Xie X, et al.
Nature
. 2007 Oct;
449(7164):913-8.
PMID: 17943131
With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over...
4.
Frazer K, Ballinger D, Cox D, Hinds D, Stuve L, Boudreau A, et al.
Nature
. 2007 Oct;
449(7164):851-61.
PMID: 17943122
We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and includes 25-35% of common...
5.
Ireland J, Carlton V, Falkowski M, Moorhead M, Tran K, Useche F, et al.
Hum Genet
. 2006 Jan;
119(1-2):75-83.
PMID: 16391945
Single nucleotide polymorphisms (SNPs) that lead to non-synonymous changes in proteins may have functional effects and be subject to selection. Hence they are of particular interest in the study of...
6.
Wang Y, Moorhead M, Karlin-Neumann G, Falkowski M, Chen C, Siddiqui F, et al.
Nucleic Acids Res
. 2005 Nov;
33(21):e183.
PMID: 16314297
Detection of genomic copy number changes has been an important research area, especially in cancer. Several high-throughput technologies have been developed to detect these changes. Features that are important for...
7.
Moorhead M, Hardenbol P, Siddiqui F, Falkowski M, Bruckner C, Ireland J, et al.
Eur J Hum Genet
. 2005 Nov;
14(2):207-15.
PMID: 16306880
High-throughput genotyping technologies that enable large association studies are already available. Tools for genotype determination starting from raw signal intensities need to be automated, robust, and flexible to provide optimal...
8.
Clayton D, Walker N, Smyth D, Pask R, Cooper J, Maier L, et al.
Nat Genet
. 2005 Oct;
37(11):1243-6.
PMID: 16228001
The main problems in drawing causal inferences from epidemiological case-control studies are confounding by unmeasured extraneous factors, selection bias and differential misclassification of exposure. In genetics the first of these,...
9.
Yu F, Sabeti P, Hardenbol P, Fu Q, Fry B, Lu X, et al.
PLoS Genet
. 2005 Oct;
1(3):e41.
PMID: 16205789
A region of approximately one megabase of human Chromosome 12 shows extensive linkage disequilibrium in Utah residents with ancestry from northern and western Europe. This strikingly large linkage disequilibrium block...
10.
Faham M, Zheng J, Moorhead M, Fakhrai-Rad H, Namsaraev E, Wong K, et al.
Proc Natl Acad Sci U S A
. 2005 Oct;
102(41):14717-22.
PMID: 16203980
Identification of the genetic basis of common disease may require comprehensive sequence analysis of coding regions and regulatory elements in patients and controls to find genetic effects caused by rare...