Andrew Boudreau
Overview
Explore the profile of Andrew Boudreau including associated specialties, affiliations and a list of published articles.
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8
Citations
3697
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Recent Articles
1.
Dang K, Castello G, Clarke S, Li Y, Balasubramani A, Boudreau A, et al.
J Immunother Cancer
. 2021 Jun;
9(6).
PMID: 34088740
Background: Therapeutic options currently available for metastatic castration-resistant prostate cancer (mCRPC) do not extend median overall survival >6 months. Therefore, the development of novel and effective therapies for mCRPC represents...
2.
Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies
Trinklein N, Pham D, Schellenberger U, Buelow B, Boudreau A, Choudhry P, et al.
MAbs
. 2019 Jan;
11(4):639-652.
PMID: 30698484
T-cell-recruiting bispecific antibodies (T-BsAbs) have shown potent tumor killing activity in humans, but cytokine release-related toxicities have affected their clinical utility. The use of novel anti-CD3 binding domains with more...
3.
Clarke S, Ma B, Trinklein N, Schellenberger U, Osborn M, Ouisse L, et al.
Front Immunol
. 2019 Jan;
9:3037.
PMID: 30666250
Heavy chain-only antibodies (HCAbs) do not associate with light chains and their V regions are functional as single domains, forming the smallest active antibody fragment. These V regions are ideal...
4.
Harris K, Force Aldred S, Davison L, Ogana H, Boudreau A, Bruggemann M, et al.
Front Immunol
. 2018 May;
9:889.
PMID: 29740455
We created a novel transgenic rat that expresses human antibodies comprising a diverse repertoire of heavy chains with a single common rearranged kappa light chain (IgKV3-15-JK1). This fixed light chain...
5.
Sabeti P, Fry B, Lohmueller J, Hostetter E, Cotsapas C, Xie X, et al.
Nature
. 2007 Oct;
449(7164):913-8.
PMID: 17943131
With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over...
6.
Frazer K, Ballinger D, Cox D, Hinds D, Stuve L, Boudreau A, et al.
Nature
. 2007 Oct;
449(7164):851-61.
PMID: 17943122
We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and includes 25-35% of common...
7.
Faham M, Zheng J, Moorhead M, Fakhrai-Rad H, Namsaraev E, Wong K, et al.
Proc Natl Acad Sci U S A
. 2005 Oct;
102(41):14717-22.
PMID: 16203980
Identification of the genetic basis of common disease may require comprehensive sequence analysis of coding regions and regulatory elements in patients and controls to find genetic effects caused by rare...
8.
Hardenbol P, Yu F, Belmont J, MacKenzie J, Bruckner C, Brundage T, et al.
Genome Res
. 2005 Feb;
15(2):269-75.
PMID: 15687290
Large-scale genetic studies are highly dependent on efficient and scalable multiplex SNP assays. In this study, we report the development of Molecular Inversion Probe technology with four-color, single array detection,...