Thomas C T Michaels
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Explore the profile of Thomas C T Michaels including associated specialties, affiliations and a list of published articles.
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71
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2269
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Recent Articles
1.
Wei J, Meisl G, Dear A, Michaels T, Knowles T
Annu Rev Biophys
. 2025 Feb;
PMID: 39929552
Low-molecular-weight oligomers formed from amyloidogenic peptides and proteins have been identified as key cytotoxins across a range of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. Developing therapeutic strategies that...
2.
Schmit J, Michaels T
Phys Rev E
. 2024 Jul;
109(6-1):064401.
PMID: 39020956
We present a theoretical analysis of phase-separated compartments to facilitate enzymatic chemical reactions. While phase separation can facilitate reactions by increasing local concentration, it can also hinder the mobility of...
3.
Dear A, Teng X, Ball S, Lewin J, Horne R, Clow D, et al.
Chem Sci
. 2024 May;
15(19):7229-7242.
PMID: 38756798
The central hallmark of Parkinson's disease pathology is the aggregation of the α-synuclein protein, which, in its healthy form, is associated with lipid membranes. Purified monomeric α-synuclein is relatively stable...
4.
Emmanouilidis L, Bartalucci E, Kan Y, Ijavi M, Perez M, Afanasyev P, et al.
Nat Chem Biol
. 2024 Mar;
20(8):1044-1052.
PMID: 38467846
Phase transitions are important to understand cell dynamics, and the maturation of liquid droplets is relevant to neurodegenerative disorders. We combined NMR and Raman spectroscopies with microscopy to follow, over...
5.
Curk S, Krausser J, Meisl G, Frenkel D, Linse S, Michaels T, et al.
Proc Natl Acad Sci U S A
. 2024 Feb;
121(7):e2220075121.
PMID: 38335256
Self-replication of amyloid fibrils via secondary nucleation is an intriguing physicochemical phenomenon in which existing fibrils catalyze the formation of their own copies. The molecular events behind this fibril surface-mediated...
6.
Pang K, Yang Y, Zhang W, Ho Y, Sormanni P, Michaels T, et al.
Biotechnol Adv
. 2023 Jun;
67:108192.
PMID: 37290583
In antibody development and manufacturing, protein aggregation is a common challenge that can lead to serious efficacy and safety issues. To mitigate this problem, it is important to investigate its...
7.
Dada S, Hardenberg M, Toprakcioglu Z, Mrugalla L, Cali M, McKeon M, et al.
Proc Natl Acad Sci U S A
. 2023 Feb;
120(9):e2208792120.
PMID: 36802433
The aggregation of α-synuclein into amyloid fibrils has been under scrutiny in recent years because of its association with Parkinson's disease. This process can be triggered by a lipid-dependent nucleation...
8.
Staats R, Michaels T, Flagmeier P, Chia S, Horne R, Habchi J, et al.
Commun Chem
. 2023 Jan;
3(1):191.
PMID: 36703335
The aggregation of α-synuclein is a central event in Parkinsons's disease and related synucleinopathies. Since pharmacologically targeting this process, however, has not yet resulted in approved disease-modifying treatments, there is...
9.
Ponisch W, Michaels T, Weber C
Biophys J
. 2022 Nov;
122(1):197-214.
PMID: 36369755
Biomolecular condensates in living cells can exhibit a complex rheology, including viscoelastic and glassy behavior. This rheological behavior of condensates was suggested to regulate polymerization of cytoskeletal filaments and aggregation...
10.
Qian D, Michaels T, Knowles T
J Phys Chem Lett
. 2022 Aug;
13(33):7853-7860.
PMID: 35977086
A self-consistent analytical solution for binodal concentrations of the two-component Flory-Huggins phase separation model is derived. We show that this form extends the validity of the Ginzburg-Landau expansion away from...