Alexander J Dear
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Explore the profile of Alexander J Dear including associated specialties, affiliations and a list of published articles.
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31
Citations
614
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Recent Articles
1.
Wei J, Meisl G, Dear A, Michaels T, Knowles T
Annu Rev Biophys
. 2025 Feb;
PMID: 39929552
Low-molecular-weight oligomers formed from amyloidogenic peptides and proteins have been identified as key cytotoxins across a range of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. Developing therapeutic strategies that...
2.
Xu C, Meisl G, Andrzejewska E, Krainer G, Dear A, Castellana-Cruz M, et al.
Nat Commun
. 2024 Aug;
15(1):7083.
PMID: 39153989
Oligomeric species arising during the aggregation of α-synuclein are implicated as a major source of toxicity in Parkinson's disease, and thus a major potential drug target. However, both their mechanism...
3.
Dear A, Meisl G, Taylor C, Capasso Palmiero U, Stubbe S, Liu Q, et al.
Nanoscale
. 2024 Aug;
16(34):16172-16182.
PMID: 39135495
Functional amyloids formed by the protein FapC in bacteria are key structural components of biofilms, which mediate chronic infections and also contribute to antimicrobial resistance. Here, we combine kinetic experiments...
4.
Axell E, Hu J, Lindberg M, Dear A, Ortigosa-Pascual L, Andrzejewska E, et al.
Proc Natl Acad Sci U S A
. 2024 Jun;
121(25):e2322572121.
PMID: 38875148
Shear forces affect self-assembly processes ranging from crystallization to fiber formation. Here, the effect of mild agitation on amyloid fibril formation was explored for four peptides and investigated in detail...
5.
Dear A, Thacker D, Wennmalm S, Ortigosa-Pascual L, Andrzejewska E, Meisl G, et al.
ACS Chem Neurosci
. 2024 May;
15(11):2296-2307.
PMID: 38785363
Oligomeric assemblies consisting of only a few protein subunits are key species in the cytotoxicity of neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases. Their lifetime in solution and abundance,...
6.
Dear A, Teng X, Ball S, Lewin J, Horne R, Clow D, et al.
Chem Sci
. 2024 May;
15(19):7229-7242.
PMID: 38756798
The central hallmark of Parkinson's disease pathology is the aggregation of the α-synuclein protein, which, in its healthy form, is associated with lipid membranes. Purified monomeric α-synuclein is relatively stable...
7.
Dear A, Garcia G, Meisl G, Collins G, Knowles T, Goldberg A
Proc Natl Acad Sci U S A
. 2024 Apr;
121(18):e2313107121.
PMID: 38652742
Full understanding of proteostasis and energy utilization in cells will require knowledge of the fraction of cell proteins being degraded with different half-lives and their rates of synthesis. We therefore...
8.
Thacker D, Willas A, Dear A, Linse S
ACS Chem Neurosci
. 2022 Nov;
13(23):3477-3487.
PMID: 36411082
The self-assembly of the amyloid β 42 (Aβ42) peptide is linked to Alzheimer's disease, and oligomeric intermediates are linked to neuronal cell death during the pathology of the disease. These...
9.
Michaels T, Dear A, Cohen S, Vendruscolo M, Knowles T
J Chem Phys
. 2022 Apr;
156(16):164904.
PMID: 35490011
Protein self-assembly into amyloid fibrils underlies several neurodegenerative conditions, including Alzheimer's and Parkinson's diseases. It has become apparent that the small oligomers formed during this process constitute neurotoxic molecular species...
10.
Braun G, Dear A, Sanagavarapu K, Zetterberg H, Linse S
Chem Sci
. 2022 Mar;
13(8):2423-2439.
PMID: 35310497
The pathology of Alzheimer's disease is connected to the aggregation of β-amyloid (Aβ) peptide, which exists as a number of length-variants. Truncations and extensions are found at both the N-...