Thomas C Rosen
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Explore the profile of Thomas C Rosen including associated specialties, affiliations and a list of published articles.
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6
Citations
23
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Recent Articles
1.
Hruschka S, Rosen T, Yoshida S, Kirk K, Frohlich R, Wibbeling B, et al.
Bioorg Med Chem
. 2008 Jul;
16(15):7148-66.
PMID: 18640844
A series of racemic, diastereoisomeric aryl cyclopropylamines substituted with fluorine in the 2-position and electron-donating and electron-withdrawing groups on the aromatic ring have been prepared. These represent analogues of the...
2.
Rosen T, Yoshida S, Frohlich R, Kirk K, Haufe G
J Med Chem
. 2004 Nov;
47(24):5860-71.
PMID: 15537343
A series of para-substituted diastereopure cis- and trans-2-fluoro-2-arylcyclopropylamines were synthesized and these were investigated as inhibitors of microbial tyramine oxidase from Arthrobacter sp. All compounds were shown to be competitive...
3.
Rosen T, Yoshida S, Kirk K, Haufe G
Chembiochem
. 2004 Aug;
5(8):1033-43.
PMID: 15300824
No abstract available.
4.
Yoshida S, Rosen T, Meyer O, Sloan M, Ye S, Haufe G, et al.
Bioorg Med Chem
. 2004 Apr;
12(10):2645-52.
PMID: 15110846
Fluorinated phenylcyclopropylamines and alkylamines were examined as inhibitors of recombinant human liver monoamine oxidase A (MAO A) and B (MAO B). For a series of trans- and cis-2-fluoro-2-phenylcyclopropylamine analogues, the...
5.
Yoshida S, Meyer O, Rosen T, Haufe G, Ye S, Sloan M, et al.
J Med Chem
. 2004 Mar;
47(7):1796-806.
PMID: 15027872
Two series of diastereopure phenylcyclopropylamine analogues, 2-fluoro-2-phenylcyclopropylamines and 2-fluoro-2-phenylcyclopropylalkylamines, as well as 2-fluoro-1-phenylcyclopropylamines and 2-fluoro-1-phenylcyclopropylmethylamines, were synthesized in order to study the effects of fluorine substitution on monoamine oxidase inhibition....
6.
Rosen T, De Clercq E, Balzarini J, Haufe G
Org Biomol Chem
. 2004 Jan;
2(2):229-37.
PMID: 14737647
Diastereopure monofluorinated cyclopropanoid nucleosides were synthesized for biological studies. As key intermediates cis- and trans-(+/-)-[1-fluoro-2-(acetoxymethyl)cyclopropyl]methanol were prepared starting from diastereopure fluorinated cyclopropanecarboxylates. The latter were synthesized by copper(i)-catalyzed cyclopropanation of...