Thomas C Muir
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Explore the profile of Thomas C Muir including associated specialties, affiliations and a list of published articles.
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11
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194
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Recent Articles
1.
McCarron J, Chalmers S, Muir T
J Cell Sci
. 2007 Dec;
121(Pt 1):86-98.
PMID: 18073237
Smooth muscle responds to activation of the inositol (1,4,5)-trisphosphate receptor [Ins(1,4,5)P(3)R] with a graded concentration-dependent ("quantal") Ca2+ release from the sarcoplasmic reticulum (SR) store. Graded release seems incompatible both with...
2.
McCarron J, Chalmers S, Bradley K, Macmillan D, Muir T
Cell Calcium
. 2006 Oct;
40(5-6):461-93.
PMID: 17069885
In smooth muscle, Ca(2+) controls diverse activities including cell division, contraction and cell death. Of particular significance in enabling Ca(2+) to perform these multiple functions is the cell's ability to...
3.
Macmillan D, Currie S, Bradley K, Muir T, McCarron J
J Cell Sci
. 2005 Nov;
118(Pt 23):5443-51.
PMID: 16278292
Ca2+ release from the sarcoplasmic reticulum (SR) by the IP3 receptors (IP3Rs) crucially regulates diverse cell signalling processes from reproduction to apoptosis. Release from the IP3R may be modulated by...
4.
Macmillan D, Chalmers S, Muir T, McCarron J
J Physiol
. 2005 Oct;
569(Pt 2):533-44.
PMID: 16195318
Smooth muscle responds to IP3-generating (sarcolemma acting) neurotransmitters and hormones by releasing Ca2+ from the sarcoplasmic reticulum (SR) via IP3 receptors (IP3Rs). This release may propagate as Ca2+ waves. The...
5.
McCarron J, Bradley K, Macmillan D, Chalmers S, Muir T
News Physiol Sci
. 2004 May;
19:138-47.
PMID: 15143210
The sarcoplasmic reticulum (SR) and apposed regions of the sarcolemma passively trap Ca2+ entering the cell to limit the rise in cytoplasmic Ca2+ concentration without SR pump involvement. When "leaky,"...
6.
The sarcoplasmic reticulum and sarcolemma together form a passive Ca2+ trap in colonic smooth muscle
Bradley K, Craig J, Muir T, McCarron J
Cell Calcium
. 2004 May;
36(1):29-41.
PMID: 15126054
In smooth muscle, active Ca(2+) uptake into regions of sarcoplasmic reticulum (SR) which are closely apposed to the sarcolemma has been proposed to substantially limit the increase in the cytoplasmic...
7.
McCarron J, Macmillan D, Bradley K, Chalmers S, Muir T
J Biol Chem
. 2003 Dec;
279(9):8417-27.
PMID: 14660609
The cytosolic Ca(2+) concentration ([Ca(2+)](c)) controls diverse cellular events via various Ca(2+) signaling patterns; the latter are influenced by the method of cell activation. Here, in single-voltage clamped smooth muscle...
8.
Bradley K, Currie S, Macmillan D, Muir T, McCarron J
J Cell Sci
. 2003 Sep;
116(Pt 21):4291-306.
PMID: 12966165
Ca2+ release via ryanodine receptors (RyRs) is vital in cell signalling and regulates diverse activities such as gene expression and excitation-contraction coupling. Cyclic ADP ribose (cADPR), a proposed modulator of...
9.
McCarron J, Bradley K, Muir T
Novartis Found Symp
. 2002 Aug;
246:52-64; discussion 64-70, 221-7.
PMID: 12164315
In smooth muscle, transient subsarcolemma increases in Ca2+ of approximately 200 nM from the sarcoplasmic reticulum activate Ca2+-activated K+ channels (KCa) in the sarcolemma giving rise to spontaneous transient outward...
10.
McCarron J, Craig J, Bradley K, Muir T
J Cell Sci
. 2002 Apr;
115(Pt 10):2207-18.
PMID: 11973361
Many cellular functions are regulated by agonist-induced InsP(3)-evoked Ca2+ release from the internal store. In non-excitable cells, predominantly, the initial Ca2+ release from the store by InsP(3) is followed by...