Thomas C Edrington
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Explore the profile of Thomas C Edrington including associated specialties, affiliations and a list of published articles.
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10
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106
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Recent Articles
1.
Wang C, Bean G, Chen C, Kessenich C, Peng J, Visconti N, et al.
PLoS One
. 2022 Sep;
17(9):e0274204.
PMID: 36074780
The recently discovered insecticidal protein Mpp75Aa1.1 from Brevibacillus laterosporus is a member of the ETX_MTX family of beta-pore forming proteins (β-PFPs) expressed in genetically modified (GM) maize to control western...
2.
Wang R, Wang Y, Edrington T, Liu Z, Lee T, Silvanovich A, et al.
PLoS One
. 2020 Jun;
15(6):e0233745.
PMID: 32542029
The susceptibility of newly expressed proteins to digestion by gastrointestinal proteases (e.g., pepsin) has long been regarded as one of the important endpoints in the weight-of-evidence (WOE) approach to assess...
3.
Lee T, Edrington T, Bell E, Burzio L, Glenn K
Regul Toxicol Pharmacol
. 2018 Dec;
102:98-107.
PMID: 30562601
Assessing the safety of genetically engineered crops includes evaluating the risk (hazard and exposure) of consuming their newly expressed proteins. The dicamba monooxygenase (DMO) protein, introduced into soybeans to confer...
4.
Wang C, Li W, Kessenich C, Petrick J, Rydel T, Sturman E, et al.
Regul Toxicol Pharmacol
. 2018 Sep;
99:50-60.
PMID: 30196079
The lepidopteran-active Cry1A.105 protein is a chimeric three-domain insecticidal toxin with distinct structural domains derived from the naturally occurring Cry1Ab, Cry1Ac and Cry1F proteins from the soil bacterium Bacillus thuringiensis...
5.
Farmer D, Edrington T, Kessenich C, Wang C, Petrick J
Regul Toxicol Pharmacol
. 2017 Jul;
89:155-164.
PMID: 28751263
Many insect-protected crops express insecticidal crystal (Cry) proteins derived from the soil bacterium Bacillus thuringiensis (Bt), including both naturally-occurring Cry proteins and chimeric Cry proteins created through biotechnology. The Cry51Aa2...
6.
Wang R, Edrington T, Storrs S, Crowley K, Ward J, Lee T, et al.
PLoS One
. 2017 Feb;
12(2):e0171926.
PMID: 28207780
The susceptibility of a dietary protein to proteolytic degradation by digestive enzymes, such as gastric pepsin, provides information on the likelihood of systemic exposure to a structurally intact and biologically...
7.
Moar W, Evans A, Kessenich C, Baum J, Bowen D, Edrington T, et al.
J Invertebr Pathol
. 2016 May;
142:50-59.
PMID: 27235983
The need for sustainable insect pest control is driving the investigation and discovery of insecticidal proteins outside of the typical 3-domain Cry protein family from Bacillus thuringiensis (Bt). Examples include...
8.
Kucharska I, Edrington T, Liang B, Tamm L
J Biomol NMR
. 2015 Apr;
61(3-4):261-74.
PMID: 25869397
Solution NMR spectroscopy has become a robust method to determine structures and explore the dynamics of integral membrane proteins. The vast majority of previous studies on membrane proteins by solution...
9.
Edrington T, Kintz E, Goldberg J, Tamm L
J Biol Chem
. 2011 Aug;
286(45):39211-23.
PMID: 21865172
Pseudomonas aeruginosa is a major nosocomial pathogen that infects cystic fibrosis and immunocompromised patients. The impermeability of the P. aeruginosa outer membrane contributes substantially to the notorious antibiotic resistance of...
10.
Edrington T, Sokolov M, Boesze-Battaglia K
Exp Eye Res
. 2011 Mar;
92(5):439-42.
PMID: 21440543
No abstract available.