Thomas C Boothby
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Explore the profile of Thomas C Boothby including associated specialties, affiliations and a list of published articles.
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30
Citations
626
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Recent Articles
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2.
Nicholson V, Meese E, Boothby T
Prog Mol Biol Transl Sci
. 2025 Feb;
211:39-61.
PMID: 39947753
Desiccation, the extreme loss of water, poses a significant challenge to living organisms. Desiccation-tolerant organisms combat this in part by accumulating desiccation tolerance intrinsically disordered proteins (DT-IDPs) and osmolytes within...
3.
Nicholson V, Nguyen K, Gollub E, McCoy M, Yu F, Holehouse A, et al.
Protein Sci
. 2025 Jan;
34(2):e70028.
PMID: 39840786
Organisms from all kingdoms of life depend on Late Embryogenesis Abundant (LEA) proteins to survive desiccation. LEA proteins are divided into broad families distinguished by the presence of family-specific motif...
4.
Kc S, Nguyen K, Nicholson V, Walgren A, Trent T, Gollub E, et al.
Elife
. 2024 Nov;
13.
PMID: 39560655
The conformational ensemble and function of intrinsically disordered proteins (IDPs) are sensitive to their solution environment. The inherent malleability of disordered proteins, combined with the exposure of their residues, accounts...
5.
Loeffelholz J, Meese E, Giovannini I, Ullibarri K, Momeni S, Merfeld N, et al.
Biol Open
. 2024 Sep;
13(10).
PMID: 39229830
Tardigrades are known for their ability to survive extreme conditions. Reports indicate that tardigrade thermal tolerance is enhanced in the desiccated state; however, these reports have almost always used a...
6.
Romero-Perez P, Moran H, Horani A, Truong A, Manriquez-Sandoval E, Ramirez J, et al.
bioRxiv
. 2024 Aug;
PMID: 39131385
Cellular desiccation - the loss of nearly all water from the cell - is a recurring stress in an increasing number of ecosystems that can drive protein unfolding and aggregation....
7.
Swamy C, Boothby T
Elife
. 2024 Jul;
13.
PMID: 38963418
Tiny animals known as tardigrades use a combination of DNA repair machinery and a novel protein to mend their genome after intense ionizing radiation.
8.
Kc S, Nguyen K, Nicholson V, Walgren A, Trent T, Gollub E, et al.
bioRxiv
. 2024 Mar;
PMID: 38464187
The conformational ensemble and function of intrinsically disordered proteins (IDPs) are sensitive to their solution environment. The inherent malleability of disordered proteins combined with the exposure of their residues accounts...
9.
Ramirez J, Kumara U, Arulsamy N, Boothby T
BBA Adv
. 2024 Feb;
5:100115.
PMID: 38318251
Statement Of Significance: For the past three decades the anhydrobiosis field has lived with a paradox, while vitrification is necessary for survival in the dry state, it is not sufficient....
10.
Biswas S, Gollub E, Yu F, Ginell G, Holehouse A, Sukenik S, et al.
Protein Sci
. 2023 Dec;
33(2):e4872.
PMID: 38114424
To survive extreme drying (anhydrobiosis), many organisms, spanning every kingdom of life, accumulate intrinsically disordered proteins (IDPs). For decades, the ability of anhydrobiosis-related IDPs to form transient amphipathic helices has...