Thimmasettappa Thippeswamy
Overview
Explore the profile of Thimmasettappa Thippeswamy including associated specialties, affiliations and a list of published articles.
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51
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829
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Recent Articles
1.
Massey N, Vasanthi S, Gimenez-Lirola L, Tyler H, Thippeswamy T
Sci Rep
. 2025 Mar;
15(1):9021.
PMID: 40089647
Organophosphate (OP) nerve agents, such as soman (GD), pose great risk to neurological health by inhibiting acetylcholinesterase, leading to seizures, epilepsy, and behavioral deficits. While acute treatment may alleviate immediate...
2.
Putra M, Rao N, Gardner C, Liu G, Trommater J, Bunney M, et al.
Brain Commun
. 2024 Oct;
6(5):fcae327.
PMID: 39355003
Epilepsy and Alzheimer's disease share some common pathologies such as neurodegeneration, seizures and impaired cognition. However, the molecular mechanisms of these changes are still largely unknown. Fyn, a Src-family non-receptor...
3.
Meyer C, Grego E, Vasanthi S, Rao N, Massey N, Holtkamp C, et al.
Antioxidants (Basel)
. 2023 Dec;
12(12).
PMID: 38136181
NADPH oxidase (NOX) is a primary mediator of superoxides, which promote oxidative stress, neurodegeneration, and neuroinflammation after diisopropylfluorophosphate (DFP) intoxication. Although orally administered mitoapocynin (MPO, 10 mg/kg), a mitochondrial-targeted NOX...
4.
Putra M, Vasanthi S, Rao N, Meyer C, Van Otterloo M, Thangi L, et al.
J Pharmacol Exp Ther
. 2023 Dec;
388(2):724-738.
PMID: 38129129
Organophosphate (OP) nerve agent (OPNA) intoxication leads to long-term brain dysfunctions. The ineffectiveness of current treatments for OPNA intoxication prompts a quest for the investigation of the mechanism and an...
5.
Vasanthi S, Massey N, Nair S, Mochel J, Showman L, Thippeswamy T
Front Vet Sci
. 2023 Nov;
10:1297221.
PMID: 38026620
Saracatinib/AZD0530 (SAR), a Src tyrosine kinase inhibitor, mitigates seizure-induced brain pathology in epilepsy models upon repeated oral dosing. However, repeated dosing is stressful and can be challenging in some seizing...
6.
Rao N, Putra M, Meyer C, Almanza A, Thippeswamy T
Front Mol Neurosci
. 2023 Nov;
16:1294514.
PMID: 38025259
Neurodegeneration and neuroinflammation are key processes of epileptogenesis in temporal lobe epilepsy (TLE). A considerable number (∼30%) of patients with epilepsy are resistant to currently available antiseizure drugs and thus...
7.
Vasanthi S, Rao N, Samidurai M, Massey N, Meyer C, Gage M, et al.
J Neuroinflammation
. 2023 Jul;
20(1):163.
PMID: 37438764
Background: Acute exposure to seizurogenic organophosphate (OP) nerve agents (OPNA) such as diisopropylfluorophosphate (DFP) or soman (GD), at high concentrations, induce immediate status epilepticus (SE), reactive gliosis, neurodegeneration, and epileptogenesis...
8.
Meyer C, Rao N, Vasanthi S, Pereira B, Gage M, Putra M, et al.
Front Cell Neurosci
. 2023 Jul;
17:1195843.
PMID: 37416507
Organophosphates (OP) are highly toxic chemical nerve agents that have been used in chemical warfare. Currently, there are no effective medical countermeasures (MCMs) that mitigate the chronic effects of OP...
9.
Gage M, Vinithakumari A, Mooyottu S, Thippeswamy T
Front Microbiomes
. 2023 Jun;
1.
PMID: 37304619
Organophosphate nerve agents (OPNAs) act as irreversible inhibitors of acetylcholinesterase and can lead to cholinergic crisis including salivation, lacrimation, urination, defecation, gastrointestinal distress, respiratory distress, and seizures. Although the OPNAs...
10.
Vasanthi S, Rao N, Samidurai M, Massey N, Meyer C, Gage M, et al.
Res Sq
. 2023 May;
PMID: 37214912
Acute exposure to seizurogenic organophosphate (OP) nerve agents (OPNA) such as diisopropylfluorophosphate (DFP) or soman (GD), at high concentrations, induce immediate (SE), reactive gliosis, neurodegeneration, and epileptogenesis as a consequence....