Thies Rosner
Overview
Explore the profile of Thies Rosner including associated specialties, affiliations and a list of published articles.
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Articles
30
Citations
508
Followers
0
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Recent Articles
1.
Zeller T, Lutz S, Munnich I, Windisch R, Hilger P, Herold T, et al.
Front Immunol
. 2022 Nov;
13:929339.
PMID: 36389667
Antibody-dependent cellular phagocytosis (ADCP) by macrophages, an important effector function of tumor targeting antibodies, is hampered by 'Don´t Eat Me!' signals such as CD47 expressed by cancer cells. Yet, human...
2.
Gehlert C, Rahmati P, Boje A, Winterberg D, Krohn S, Theocharis T, et al.
Front Immunol
. 2022 Sep;
13:957874.
PMID: 36119088
Targeting CD19 represents a promising strategy for the therapy of B-cell malignancies. Although non-engineered CD19 antibodies are poorly effective in mediating complement-dependent cytotoxicity (CDC), antibody-dependent cell-mediated cytotoxicity (ADCC) or antibody-dependent...
3.
Baumann N, Arndt C, Petersen J, Lustig M, Rosner T, Klausz K, et al.
Front Immunol
. 2022 Sep;
13:949140.
PMID: 36052078
Antibody-based immunotherapy is increasingly employed to treat acute lymphoblastic leukemia (ALL) patients. Many T-ALL cells express CD38 on their surface, which can be targeted by the CD38 antibody daratumumab (DARA),...
4.
Vogiatzi F, Heymann J, Muller K, Winterberg D, Drakul A, Rosner T, et al.
Blood Adv
. 2022 Jul;
6(16):4847-4858.
PMID: 35820018
Immunotherapy has evolved as a powerful tool for the treatment of B-cell malignancies, and patient outcomes have improved by combining therapeutic antibodies with conventional chemotherapy. Overexpression of antiapoptotic B-cell lymphoma...
5.
Muller K, Vogiatzi F, Winterberg D, Rosner T, Lenk L, Bastian L, et al.
Blood
. 2022 Apr;
140(1):45-57.
PMID: 35452517
Acute lymphoblastic leukemia (ALL) is the most common malignant disease affecting children. Although therapeutic strategies have improved, T-cell acute lymphoblastic leukemia (T-ALL) relapse is associated with chemoresistance and a poor...
6.
Evers M, Rosner T, Dunkel A, Jansen J, Baumann N, Ten Broeke T, et al.
Blood Adv
. 2021 Sep;
5(19):3807-3820.
PMID: 34525171
Blockade of the CD47-SIRPα axis improves lymphoma cell killing by myeloid effector cells, which is an important effector mechanism for CD20 antibodies in vivo. The approved CD20 antibodies rituximab, ofatumumab,...
7.
Winterberg D, Lenk L, Osswald M, Vogiatzi F, Gehlert C, Frielitz F, et al.
J Clin Med
. 2021 Jul;
10(12).
PMID: 34203833
B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most frequent malignancy in children and also occurs in adulthood. Despite high cure rates, BCP-ALL chemotherapy can be highly toxic. This type...
8.
Baumann N, Rosner T, Jansen J, Chan C, Marie Eichholz K, Klausz K, et al.
Cancer Sci
. 2021 May;
112(8):3029-3040.
PMID: 34058788
Integrin associated protein (CD47) is an important target in immunotherapy, as it is expressed as a "don't eat me" signal on many tumor cells. Interference with its counter molecule signal...
9.
Heemskerk N, Gruijs M, Temming A, Heineke M, Gout D, Hellingman T, et al.
J Clin Invest
. 2021 Feb;
131(6).
PMID: 33561014
Most clinically used anticancer mAbs are of the IgG isotype, which can eliminate tumor cells through NK cell-mediated antibody-dependent cellular cytotoxicity and macrophage-mediated antibody-dependent phagocytosis. IgG, however, ineffectively recruits neutrophils...
10.
Macarron Palacios A, Grzeschik J, Deweid L, Krah S, Zielonka S, Rosner T, et al.
Front Immunol
. 2020 Dec;
11:560244.
PMID: 33324393
The B-cell receptor (BCR) is a key player of the adaptive immune system. It is a unique part of immunoglobulin (Ig) molecules expressed on the surface of B cells. In...