Thierry Louat
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Explore the profile of Thierry Louat including associated specialties, affiliations and a list of published articles.
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20
Citations
242
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Recent Articles
1.
Herman J, Vanstreels E, Bardiot D, Prota A, Gaillard N, Gao L, et al.
PLoS One
. 2024 Nov;
19(11):e0307153.
PMID: 39509402
Microtubule-targeting agents are an important class of anti-cancer drugs; their full potential is however not realized because of significant myelotoxicity and neurotoxicity. We here report 3-nitropyridine analogues as a novel...
2.
Adasme M, Parisi D, Van Belle K, Salentin S, Haupt V, Jennings G, et al.
PLoS One
. 2020 May;
15(5):e0233089.
PMID: 32459810
Many drugs are promiscuous and bind to multiple targets. On the one hand, these targets may be linked to unwanted side effects, but on the other, they may achieve a...
3.
Van Belle K, Herman J, Waer M, Sprangers B, Louat T
J Immunol Res
. 2018 Oct;
2018:2505818.
PMID: 30276218
B cells are pathogenic in various disease processes and therefore represent an interesting target for the development of novel immunosuppressants. In the search for new therapeutic molecules, we utilized an...
4.
Reuberson J, Horsley H, Franklin R, Ford D, Neuss J, Brookings D, et al.
J Med Chem
. 2018 Jun;
61(15):6705-6723.
PMID: 29952567
The primary target of a novel series of immunosuppressive 7-piperazin-1-ylthiazolo[5,4- d]pyrimidin-5-amines was identified as the lipid kinase, PI4KIIIβ. Evaluation of the series highlighted their poor solubility and unwanted off-target activities....
5.
Van Belle K, Herman J, Boon L, Waer M, Sprangers B, Louat T
J Immunol Res
. 2017 Jan;
2016:5281823.
PMID: 28116319
B cell specific immunomodulatory drugs still remain an unmet medical need. Utilisation of validated simplified in vitro models would allow readily obtaining new insights in the complexity of B cell...
6.
Barbieri K, Ercolin L, Louat T, Polesi M, Chin C, Zeppone I, et al.
Med Chem
. 2016 Dec;
13(2):159-167.
PMID: 27924728
Background: Immunosuppressive drugs are widely used to prevent and treat allograft rejection and autoimmune diseases. Mycophenolic acid (MPA) and its derivatives are currently one of the most prescribed immunosuppressive drugs;...
7.
Windey K, De Preter V, Huys G, Broekaert W, Delcour J, Louat T, et al.
Br J Nutr
. 2014 Dec;
113(2):225-38.
PMID: 25498469
Wheat bran extract (WBE), containing arabinoxylan-oligosaccharides that are potential prebiotic substrates, has been shown to modify bacterial colonic fermentation in human subjects and to beneficially affect the development of colorectal...
8.
Markad P, Sonawane D, Ghosh S, Chopade B, Kumbhar N, Louat T, et al.
Bioorg Med Chem
. 2014 Oct;
22(21):5776-82.
PMID: 25305010
An efficient and practical strategy for the synthesis of (3R,4s,5S)-4-(2-hydroxyethyl) piperidine-3,4,5-triol and its N-alkyl derivatives 8a-f, starting from the D-glucose, is reported. The chiral pool methodology involves preparation of the...
9.
Windey K, Francois I, Broekaert W, De Preter V, Delcour J, Louat T, et al.
Mol Nutr Food Res
. 2014 Aug;
58(11):2206-18.
PMID: 25164793
Scope: In vitro and animal studies have shown differential colonic fermentation of structurally different prebiotics. We evaluated the impact of two structurally different prebiotics (wheat bran extract (WBE, containing arabinoxylan-oligosaccharides)...
10.
Stella A, Van Belle K, De Jonghe S, Louat T, Herman J, Rozenski J, et al.
Bioorg Med Chem
. 2013 Jan;
21(5):1209-18.
PMID: 23347804
A series of novel pyrimidine analogues were synthesized and evaluated for immunosuppressive activity in the Mixed Lymphocyte Reaction assay, which is well-known as the in vitro model for in vivo...