Therese Horch
Overview
Explore the profile of Therese Horch including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
27
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Recent Articles
1.
Zdouc M, Blin K, Louwen N, Navarro J, Loureiro C, Bader C, et al.
Nucleic Acids Res
. 2024 Dec;
53(D1):D678-D690.
PMID: 39657789
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is...
2.
Klapper M, Hubner A, Ibrahim A, Wasmuth I, Borry M, Haensch V, et al.
Science
. 2023 May;
380(6645):619-624.
PMID: 37141315
Major advances over the past decade in the field of ancient DNA are providing access to past paleogenomic diversity, but the diverse functions and biosynthetic capabilities of this growing paleome...
3.
A Specialized Polythioamide-Binding Protein Confers Antibiotic Self-Resistance in Anaerobic Bacteria
Gude F, Molloy E, Horch T, Dell M, Dunbar K, Krabbe J, et al.
Angew Chem Int Ed Engl
. 2022 Jul;
61(37):e202206168.
PMID: 35852818
Understanding antibiotic resistance mechanisms is central to the development of anti-infective therapies and genomics-based drug discovery. Yet, many knowledge gaps remain regarding the resistance strategies employed against novel types of...
4.
Horch T, Molloy E, Bredy F, Haensch V, Scherlach K, Dunbar K, et al.
Angew Chem Int Ed Engl
. 2022 Jun;
61(32):e202205409.
PMID: 35656913
Benzoxazole scaffolds feature prominently in diverse synthetic and natural product-derived pharmaceuticals. Our understanding of their bacterial biosynthesis is, however, limited to ortho-substituted heterocycles from actinomycetes. We report an overlooked biosynthetic...
5.
Molloy E, Dell M, Hansch V, Dunbar K, Feldmann R, Oberheide A, et al.
Angew Chem Int Ed Engl
. 2021 Feb;
60(19):10670-10679.
PMID: 33625794
Clostridia coordinate many important processes such as toxin production, infection, and survival by density-dependent communication (quorum sensing) using autoinducing peptides (AIPs). Although clostridial AIPs have been proposed to be (thio)lactone-containing...