Thea Shavlakadze
Overview
Explore the profile of Thea Shavlakadze including associated specialties, affiliations and a list of published articles.
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18
Citations
582
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Recent Articles
1.
Chai R, Vukovic J, Dunlop S, Grounds M, Shavlakadze T
PLoS One
. 2011 Dec;
6(12):e28090.
PMID: 22164231
Reasons for the progressive age-related loss of skeletal muscle mass and function, namely sarcopenia, are complex. Few studies describe sarcopenia in mice, although this species is the mammalian model of...
2.
Radley-Crabb H, Terrill J, Shavlakadze T, Tonkin J, Arthur P, Grounds M
Neuromuscul Disord
. 2011 Aug;
22(2):170-82.
PMID: 21835619
The extent of muscle pathology in sedentary adult mdx mice is very low and treadmill exercise is often used to increase myofibre necrosis; however, the early events in dystrophic muscle...
3.
Klyen B, Shavlakadze T, Radley-Crabb H, Grounds M, Sampson D
J Biomed Opt
. 2011 Aug;
16(7):076013.
PMID: 21806274
Three-dimensional optical coherence tomography (3D-OCT) was used to image the structure and pathology of skeletal muscle tissue from the treadmill-exercised mdx mouse model of human Duchenne muscular dystrophy. Optical coherence...
4.
Tohma H, Hepworth A, Shavlakadze T, Grounds M, Arthur P
J Histochem Cytochem
. 2011 Aug;
59(8):769-79.
PMID: 21804079
Ceroid and lipofuscin are autofluorescent granules thought to be generated as a consequence of chronic oxidative stress. Because ceroid and lipofuscin are persistent in tissue, their measurement can provide a...
5.
Grounds M, Shavlakadze T
Bioessays
. 2011 Apr;
33(6):458-68.
PMID: 21500235
We hypothesise that the sarcolemma of an actively growing myofibre has different properties to the sarcolemma of a mature adult myofibre. Such fundamentally different properties have clinical consequences for the...
6.
Shavlakadze T, Grounds M
J Appl Physiol (1985)
. 2010 Jun;
108(6):1829.
PMID: 20527702
No abstract available.
7.
Shavlakadze T, Chai J, Maley K, Cozens G, Grounds G, Winn N, et al.
J Cell Sci
. 2010 Feb;
123(Pt 6):960-71.
PMID: 20179101
Here, we characterise new strains of normal and dystrophic (mdx) mice that overexpress Class 2 IGF-1 Ea in skeletal myofibres. We show that transgenic mice have increased muscle levels of...
8.
Delayed but excellent myogenic stem cell response of regenerating geriatric skeletal muscles in mice
Shavlakadze T, McGeachie J, Grounds M
Biogerontology
. 2009 Dec;
11(3):363-76.
PMID: 20033288
The ability of very old animals to make new muscle after injury remains controversial. This issue has major implications for the regenerative potential of damaged geriatric human muscle, to age-related...
9.
Waters F, Shavlakadze T, McIldowie M, Piggott M, Grounds M
Mol Cell Biochem
. 2009 Oct;
337(1-2):119-31.
PMID: 19859789
Tumour Necrosis Factor (TNF) plays a major role in exacerbating necrosis of dystrophic muscle; however, the precise molecular mechanism underlying this effect of TNF is unknown. This study investigates the...
10.
Oxidative stress as a therapeutic target during muscle wasting: considering the complex interactions
Arthur P, Grounds M, Shavlakadze T
Curr Opin Clin Nutr Metab Care
. 2008 Jun;
11(4):408-16.
PMID: 18542000
Purpose Of Review: The aim of this overview is to highlight the multiple ways in which oxidative stress could be exacerbating muscle wasting. Understanding these interactions in vivo will assist...