Thaddaeus Kwan
Overview
Explore the profile of Thaddaeus Kwan including associated specialties, affiliations and a list of published articles.
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9
Citations
155
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Recent Articles
1.
Guha A, Waris S, Nabors L, Filippova N, Gorospe M, Kwan T, et al.
Adv Drug Deliv Rev
. 2021 Dec;
181:114082.
PMID: 34923029
Glioblastoma (GBM) is a malignant and aggressive brain tumor with a median survival of ∼15 months. Resistance to treatment arises from the extensive cellular and molecular heterogeneity in the three...
2.
Chellappan R, Guha A, Si Y, Kwan T, Nabors L, Filippova N, et al.
Glia
. 2021 Sep;
70(1):155-172.
PMID: 34533864
Glial activation with the production of pro-inflammatory mediators is a major driver of disease progression in neurological processes ranging from acute traumatic injury to chronic neurodegenerative diseases such as amyotrophic...
3.
Si Y, Kazamel M, Benatar M, Wuu J, Kwon Y, Kwan T, et al.
Sci Rep
. 2021 Jun;
11(1):12062.
PMID: 34103575
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive muscle weakness. Skeletal muscle is a prime source for biomarker discovery since it is one of the earliest...
4.
Kwan T, Kazamel M, Thoenes K, Si Y, Jiang N, King P
Sci Rep
. 2020 Oct;
10(1):16679.
PMID: 33028902
Skeletal muscle and the neuromuscular junction are the earliest sites to manifest pathological changes in amyotrophic lateral sclerosis (ALS). Based on prior studies, we have identified a molecular signature in...
5.
Si Y, Kazamel M, Kwon Y, Lee I, Anderson T, Zhou S, et al.
J Steroid Biochem Mol Biol
. 2020 Mar;
200:105650.
PMID: 32142934
Extra-renal expression of Cytochrome P450 Family 27 Subfamily B Member 1 (CYP27B1) has been well recognized and reflects the importance of intracrine/paracrine vitamin D signaling in different tissues under physiological...
6.
Kwan T, Thompson S
Cold Spring Harb Perspect Biol
. 2018 Jul;
11(4).
PMID: 29959190
The vast majority of eukaryotic messenger RNAs (mRNAs) initiate translation through a canonical, cap-dependent mechanism requiring a free 5' end and 5' cap and several initiation factors to form a...
7.
Kwan T, Floyd C, Patel J, Mohaimany-Aponte A, King P
Neurosci Lett
. 2017 May;
651:140-145.
PMID: 28487080
We recently showed that the RNA regulator, HuR, is translocated to the cytoplasm in astrocytes in the acute phase of spinal cord injury (SCI), consistent with its activation. HuR positively...
8.
Kwan T, Floyd C, Kim S, King P
J Neurotrauma
. 2016 Nov;
34(6):1249-1259.
PMID: 27852147
Inflammation plays a prominent role in the events following traumatic injury to the central nervous system (CNS). The initial inflammatory response is driven by mediators such as tumor necrosis factor...
9.
Lu L, Zheng L, Si Y, Luo W, Dujardin G, Kwan T, et al.
J Biol Chem
. 2014 Sep;
289(46):31792-31804.
PMID: 25239623
Posttranscriptional gene regulation is governed by a network of RNA-binding proteins (RBPs) that interact with regulatory elements in the mRNA to modulate multiple molecular processes, including splicing, RNA transport, RNA...