Tetyana Dodatko
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Explore the profile of Tetyana Dodatko including associated specialties, affiliations and a list of published articles.
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20
Citations
253
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Recent Articles
1.
Richert A, Zhang Y, Bharathi S, Hernandez A, Dodatko T, Bons J, et al.
bioRxiv
. 2025 Feb;
PMID: 39990440
Glutaric aciduria type-1 (GA1) is an inherited mitochondrial neurometabolic disorder with a poorly understood pathogenesis and unmet medical needs. GA1 can be diagnosed via its hallmark biochemical signature consisting of...
2.
Wu R, Khamrui S, Dodatko T, Leandro J, Sabovic A, Violante S, et al.
ACS Chem Biol
. 2024 Jun;
19(7):1544-1553.
PMID: 38915184
Glutaric Aciduria Type 1 (GA1) is a serious inborn error of metabolism with no pharmacological treatments. A novel strategy to treat this disease is to divert the toxic biochemical intermediates...
3.
Khamrui S, Dodatko T, Wu R, Leandro J, Sabovic A, Violante S, et al.
bioRxiv
. 2024 Feb;
PMID: 38370847
Glutaric Aciduria Type 1 (GA1) is a serious inborn error of metabolism with no pharmacological treatments. A novel strategy to treat this disease is to divert the toxic biochemical intermediates...
4.
Savic R, Yang J, Koplev S, An M, Patel P, OBrien R, et al.
Cell Rep
. 2023 Nov;
42(11):113371.
PMID: 37938972
Senescent cells are a major contributor to age-dependent cardiovascular tissue dysfunction, but knowledge of their in vivo cell markers and tissue context is lacking. To reveal tissue-relevant senescence biology, we...
5.
Houten S, Dodatko T, Dwyer W, Violante S, Chen H, Stauffer B, et al.
J Inherit Metab Dis
. 2023 Jun;
46(5):931-942.
PMID: 37309295
Toxicity of accumulating substrates is a significant problem in several disorders of valine and isoleucine degradation notably short-chain enoyl-CoA hydratase (ECHS1 or crotonase) deficiency, 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency, propionic acidemia...
6.
Peters L, Friedman J, Stojmirovic A, Hagen J, Houten S, Dodatko T, et al.
Commun Biol
. 2023 Jan;
6(1):95.
PMID: 36694043
Previous studies have conducted time course characterization of murine colitis models through transcriptional profiling of differential expression. We characterize the transcriptional landscape of acute and chronic models of dextran sodium...
7.
Leandro J, Khamrui S, Suebsuwong C, Chen P, Secor C, Dodatko T, et al.
Open Biol
. 2022 Sep;
12(9):220179.
PMID: 36128717
In humans, a single enzyme 2-aminoadipic semialdehyde synthase (AASS) catalyses the initial two critical reactions in the lysine degradation pathway. This enzyme evolved to be a bifunctional enzyme with both...
8.
DiNarzo A, Houten S, Kosoy R, Huang R, Vaz F, Hou R, et al.
Gastroenterology
. 2021 Nov;
162(3):828-843.e11.
PMID: 34780722
Background & Aims: Polygenic and environmental factors are underlying causes of inflammatory bowel disease (IBD). We hypothesized that integration of the genetic loci controlling a metabolite's abundance, with known IBD...
9.
Belbin G, Rutledge S, Dodatko T, Cullina S, Turchin M, Kohli S, et al.
Am J Hum Genet
. 2021 Oct;
108(11):2099-2111.
PMID: 34678161
The integration of genomic data into health systems offers opportunities to identify genomic factors underlying the continuum of rare and common disease. We applied a population-scale haplotype association approach based...
10.
Ranea-Robles P, Violante S, Argmann C, Dodatko T, Bhattacharya D, Chen H, et al.
Cell Mol Life Sci
. 2021 Jun;
78(14):5631-5646.
PMID: 34110423
Peroxisomes play an essential role in the β-oxidation of dicarboxylic acids (DCAs), which are metabolites formed upon ω-oxidation of fatty acids. Genetic evidence linking transporters and enzymes to specific DCA...