Tetsuya Hosooka
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Explore the profile of Tetsuya Hosooka including associated specialties, affiliations and a list of published articles.
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44
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914
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Recent Articles
1.
Tachibana S, Hayashi S, Ikuta K, Anjiki K, Onoi Y, Suda Y, et al.
Bone
. 2024 Oct;
190:117302.
PMID: 39437873
Objective: The role of Krüppel-like zinc finger transcription factor 15 (KLF15) in endochondral ossification during fracture healing remains unexplored. In this study, we aimed to elucidate the impact of KLF15...
2.
Akiyama M, Ishikawa S, Hosooka T, Iwase M, Uchida K
Biosci Biotechnol Biochem
. 2024 Oct;
88(12):1472-1478.
PMID: 39363205
Temperature detection and temperature preference are critical for the maintenance of thermal homeostasis and protection from noxious temperature. Methods to measure the time spent on plates of different temperatures such...
3.
Nomura K, Kinoshita S, Mizusaki N, Senga Y, Sasaki T, Kitamura T, et al.
Mol Metab
. 2024 Jun;
86:101968.
PMID: 38885788
The transcriptional coactivator PGC-1α has been implicated in the regulation of multiple metabolic processes. However, the previously reported metabolic phenotypes of mice deficient in PGC-1α have been inconsistent. PGC-1α exists...
4.
Imamori M, Hosooka T, Imi Y, Hosokawa Y, Yamaguchi K, Itoh Y, et al.
Biochem Biophys Res Commun
. 2023 Dec;
693:149369.
PMID: 38091840
Insulin resistance in adipose tissue is thought to be a key contributor to the pathogenesis of various metabolic disorders including metabolic dysfunction-associated steatotic liver disease/metabolic dysfunction-associated steatohepatitis (MASLD/MASH), but the...
5.
Kasahara N, Imi Y, Amano R, Shinohara M, Okada K, Hosokawa Y, et al.
Sci Rep
. 2023 Nov;
13(1):18983.
PMID: 37923895
The antidiabetic drug pioglitazone ameliorates insulin resistance by activating the transcription factor PPARγ. In addition to its blood glucose-lowering action, pioglitazone exerts pleiotropic effects including amelioration of nonalcoholic fatty liver...
6.
Ikuta K, Hayashi S, Kikuchi K, Fujita M, Anjiki K, Onoi Y, et al.
Osteoarthritis Cartilage
. 2023 Aug;
32(1):28-40.
PMID: 37648149
Objective: Krüppel-like zinc finger transcription factors (KLFs) play diverse roles in mammalian cell differentiation and development. In this study, we investigated the function of KLF15 in the progression of osteoarthritis...
7.
Hosokawa Y, Hosooka T, Imamori M, Yamaguchi K, Itoh Y, Ogawa W
Hepatol Commun
. 2023 May;
7(6).
PMID: 37219877
Background: Insulin regulates various biological processes in adipocytes, and adipose tissue dysfunction due to insulin resistance in this tissue plays a central role in the development of metabolic diseases, including...
8.
Imi Y, Amano R, Kasahara N, Obana Y, Hosooka T
Biochem Biophys Rep
. 2023 May;
34:101476.
PMID: 37144119
Nicotinamide adenine dinucleotide (NAD) -dependent protein deacetylase SIRT1 plays an important role in the regulation of metabolism. Although the administration of nicotinamide mononucleotide (NMN), a key NAD intermediate, has been...
9.
Imi Y, Ogawa W, Hosooka T
Diabetol Int
. 2023 Apr;
14(2):119-124.
PMID: 37090134
Adipose tissue regulates systemic energy metabolism through adipokine production as well as energy storage and energy supply to other organs in response to changes in energy status. Adipose tissue dysfunction...
10.
Kanagaki S, Tsutsui Y, Kobayashi N, Komine T, Ito M, Akasaka Y, et al.
iScience
. 2023 Mar;
26(4):106293.
PMID: 36950117
5'-Adenosine monophosphate-activated protein kinase (AMPK) is a potential therapeutic target for various medical conditions. We here identify a small-molecule compound (RX-375) that activates AMPK and inhibits fatty acid synthesis in...