Tetsuhiro S Hatakeyama
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Explore the profile of Tetsuhiro S Hatakeyama including associated specialties, affiliations and a list of published articles.
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13
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105
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Recent Articles
1.
Yamagishi J, Hatakeyama T
Phys Rev Lett
. 2023 Jul;
131(2):028401.
PMID: 37505963
Predicting cellular metabolic states is a central problem in biophysics. Conventional approaches, however, sensitively depend on the microscopic details of individual metabolic systems. In this Letter, we derived a universal...
2.
Hatakeyama T, Kaneko K
PLoS One
. 2023 Jan;
18(1):e0277181.
PMID: 36701362
In physics of living systems, a search for relationships of a few macroscopic variables that emerge from many microscopic elements is a central issue. We evolved gene regulatory networks so...
3.
Oda A, Tamura M, Kaneko K, Ohta K, Hatakeyama T
PLoS Biol
. 2022 Nov;
20(11):e3001844.
PMID: 36342925
Cellular adaptation to stressful environments such as starvation is essential to the survival of microbial communities, but the uniform response of the cell community may lead to entire cell death...
4.
Yamagishi J, Hatakeyama T
Bull Math Biol
. 2021 Oct;
83(12):120.
PMID: 34718881
Metabolic behaviours of proliferating cells are often explained as a consequence of rational optimization of cellular growth rate, whereas microeconomics formulates consumption behaviours as optimization problems. Here, we pushed beyond...
5.
Ohbayashi R, Nakamachi A, Hatakeyama T, Watanabe S, Kanesaki Y, Chibazakura T, et al.
mBio
. 2019 Apr;
10(2).
PMID: 31015323
Homologous chromosome number (ploidy) has diversified among bacteria, archaea, and eukaryotes over evolution. In bacteria, model organisms such as possess a single chromosome encoding the entire genome during slow growth....
6.
Hatakeyama T, Furusawa C
PLoS Comput Biol
. 2017 Nov;
13(11):e1005847.
PMID: 29112954
To uncover the processes and mechanisms of cellular physiology, it first necessary to gain an understanding of the underlying metabolic dynamics. Recent studies using a constraint-based approach succeeded in predicting...
7.
Hatakeyama T, Kaneko K
Phys Rev E
. 2017 Apr;
95(3-1):030201.
PMID: 28415261
The robustness of spatial patterns against perturbations is an indispensable property of developmental processes for organisms, which need to adapt to changing environments. Although specific mechanisms for this robustness have...
8.
Young J, Hatakeyama T, Kaneko K
PLoS Comput Biol
. 2017 Mar;
13(3):e1005434.
PMID: 28288155
A most important property of biochemical systems is robustness. Static robustness, e.g., homeostasis, is the insensitivity of a state against perturbations, whereas dynamics robustness, e.g., homeorhesis, is the insensitivity of...
9.
Hatakeyama T, Kaneko K
Phys Rev Lett
. 2015 Dec;
115(21):218101.
PMID: 26636874
Circadian clocks exhibit the robustness of period and plasticity of phase against environmental changes such as temperature and nutrient conditions. Thus far, however, it is unclear how both are simultaneously...
10.
Hatakeyama T, Kaneko K
PLoS Comput Biol
. 2014 Aug;
10(8):e1003784.
PMID: 25121967
Cellular memory, which allows cells to retain information from their environment, is important for a variety of cellular functions, such as adaptation to external stimuli, cell differentiation, and synaptic plasticity....