Terhi Launiainen
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Explore the profile of Terhi Launiainen including associated specialties, affiliations and a list of published articles.
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14
Citations
179
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Recent Articles
1.
Kahma H, Aurinsalo L, Neuvonen M, Katajamaki J, Paludetto M, Viinamaki J, et al.
Eur J Pharm Sci
. 2021 Mar;
162:105810.
PMID: 33753217
We developed an in vitro high-throughput cocktail assay with nine major drug-metabolizing CYP enzymes, optimized for screening of time-dependent inhibition. The method was applied to determine the selectivity of the...
2.
Kaartinen T, Tornio A, Tapaninen T, Launiainen T, Isoherranen N, Niemi M, et al.
Clin Pharmacol Ther
. 2020 Jun;
108(6):1254-1264.
PMID: 32558923
In vitro, esomeprazole is a time-dependent inhibitor of CYP2C19. Additionally, racemic omeprazole induces CYP1A2 and omeprazole and its metabolites inhibit CYP3A4 in vitro. In this 5-phase study, 10 healthy volunteers...
3.
Hirvensalo P, Tornio A, Launiainen T, Paile-Hyvarinen M, Tapaninen T, Neuvonen M, et al.
Clin Pharmacol Ther
. 2020 Jun;
108(4):885-895.
PMID: 32498119
To investigate how variability in multiple pharmacokinetic genes associates with telmisartan exposure, we determined telmisartan single-dose (40 mg) pharmacokinetics and sequenced 379 genes in 188 healthy volunteers. Intronic UGT1A variants...
4.
Kahma H, Filppula A, Launiainen T, Viinamaki J, Neuvonen M, Evangelista E, et al.
Drug Metab Dispos
. 2019 Feb;
47(4):436-443.
PMID: 30709838
Clopidogrel acyl--d-glucuronide is a mechanism-based inhibitor of cytochrome P450 2C8 in human liver microsomes (HLMs). However, time-dependent inactivation (TDI) of CYP2C8 could not be detected in an earlier study in...
5.
Bergmann T, Filppula A, Launiainen T, Nielsen F, Backman J, Brosen K
Br J Clin Pharmacol
. 2015 Oct;
81(2):313-5.
PMID: 26446447
Aim: The aim of the present case report was to describe a novel pharmacokinetic drug–drug interaction between the antiplatelet agent clopidogrel and the antineoplastic agent paclitaxel. Methods: The patient was...
6.
Tarkiainen E, Tornio A, Holmberg M, Launiainen T, Neuvonen P, Backman J, et al.
Br J Clin Pharmacol
. 2015 Apr;
80(5):1131-8.
PMID: 25919042
Aim: The aim of the present study was to investigate the effects of the carboxylesterase 1 (CES1) c.428G > A (p.G143E, rs71647871) single nucleotide variation (SNV) on the pharmacokinetics of...
7.
Launiainen T, Ojanpera I
Drug Test Anal
. 2013 Jul;
6(4):308-16.
PMID: 23881890
Therapeutic drug concentrations measured in plasma are of limited value as reference intervals for interpretation in post-mortem (PM) toxicology. In this study, drug concentration distributions were studied in PM femoral...
8.
Launiainen T, Nupponen I, Halmesmaki E, Ojanpera I
Drug Test Anal
. 2013 Feb;
5(7):529-33.
PMID: 23389850
Meconium drug testing is a non-invasive method to detect prenatal drug exposure, which can cause severe problems for the infant, indicating the need for follow-up measures to ensure the welfare...
9.
Hakkinen M, Launiainen T, Vuori E, Ojanpera I
Forensic Sci Int
. 2012 Aug;
222(1-3):327-31.
PMID: 22884575
There is a rising trend of fatal poisonings due to medicinal opioids in several countries. The present study evaluates the drug and alcohol findings as well as the cause and...
10.
Hakkinen M, Launiainen T, Vuori E, Ojanpera I
Eur J Clin Pharmacol
. 2011 Sep;
68(3):301-9.
PMID: 21927835
Background: Although buprenorphine therapy has proved to be successful in opioid maintenance treatments, the drug is also widely abused in many countries by intravenous injection or sniffing ("snorting"). In Finland,...