Teodoro S Kaufman
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Explore the profile of Teodoro S Kaufman including associated specialties, affiliations and a list of published articles.
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77
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246
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Recent Articles
1.
Moroni A, Bottoso T, Lionello D, Vega D, Kaufman T, Calvo N
Acta Crystallogr E Crystallogr Commun
. 2024 Oct;
80(Pt 10):1064-1068.
PMID: 39372179
The mol-ecular salt sulfamethoxazolium {or 4-[(5-methyl-1,2-oxazol-3-yl)sulf-amo-yl]anilinium methyl sulfate monohydrate}, CHNOS·CHOS·HO, was prepared by the reaction of sulfamethoxazole and HSO in methanol and crystallized from methanol-ether-water. Protonation takes place at the...
2.
Vargas D, Fonzo S, Simonetti S, Kaufman T, Larghi E
Org Biomol Chem
. 2024 Sep;
22(38):7880-7894.
PMID: 39247987
Three short and efficient total syntheses of cassiarin C are reported, from a chromanone common key intermediate. A C-H activation strategy, under rhodium catalysis on its pivaloyl oxime, enabled the...
3.
Larghi E, Bracca A, Simonetti S, Kaufman T
ChemistryOpen
. 2024 Apr;
13(5):e202300306.
PMID: 38647363
Multicomponent reactions (MCRs) offer a highly useful and valuable strategy that can fulfill an important role in synthesizing complex polysubstituted compounds, by simplifying otherwise long sequences and increasing their efficiency....
4.
Moroni A, Mayoral E, Lionello D, Vega D, Kaufman T, Calvo N
Int J Pharm
. 2024 Jan;
652:123855.
PMID: 38280497
Tioconazole is an effective antifungal agent with very low solubility in aqueous media, which limits its bioavailability and efficacy. Aiming to overcome the drug limitations by improving the solubility of...
5.
Larghi E, Bracca A, Simonetti S, Kaufman T
Org Biomol Chem
. 2023 Dec;
22(3):429-465.
PMID: 38126459
The total syntheses of selected natural products using different versions of the Ugi multicomponent reaction is reviewed on a case-by-case basis. The revision covers the period 2008-2023 and includes detailed...
6.
Bolivar Avila S, Ledesma G, Kaufman T, Testero S, Larghi E
ACS Omega
. 2023 Jul;
8(25):23174-23181.
PMID: 37396254
An efficient and straightforward route toward the isatin-type natural product melosatin A is reported, employing a trisubstituted aniline as a key intermediate. The latter was synthesized in 4 steps and...
7.
Thobokholt E, Simonetti S, Kaufman T, Larghi E, Bracca A
RSC Adv
. 2023 May;
13(20):13715-13724.
PMID: 37152581
Two total syntheses of quindoline, which take place through the intermediacy of 3-nitroquinoline derivatives, are reported. The general synthetic sequence involves construction of the latter by mechanochemical condensation of benzaldehydes...
8.
Moroni A, Mayoral E, Lionello D, Vega D, Kaufman T, Calvo N
Int J Pharm
. 2023 Mar;
637:122869.
PMID: 36948477
Tioconazole is an effective antifungal agent, which has a very low solubility in aqueous media, that limits its bioavailability and efficacy. In an effort to overcome the drug limitations by...
9.
Moroni A, Calvo N, Kaufman T
J Pharm Sci
. 2023 Feb;
112(6):1523-1538.
PMID: 36822273
Nifurtimox is a nitroheterocyclic drug employed for treatment of trypanosomiases (Chagas disease and West African sleeping sickness); its use for certain cancers has also been assessed. Despite having been in...
10.
Moroni A, Mayoral E, Lionello D, Vega D, Kaufman T, Calvo N
Eur J Pharm Biopharm
. 2023 Jan;
184:25-35.
PMID: 36681284
Nifurtimox (NFX) is a nitrofuran derivative used to treat Chagas disease, a neglected disease caused by the protozoan Trypanosoma cruzi. The drug is very sparingly soluble in aqueous media and...