Tejas Dharmaraj
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Explore the profile of Tejas Dharmaraj including associated specialties, affiliations and a list of published articles.
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12
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69
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Recent Articles
1.
Kim M, Suh G, Cullen G, Perez Rodriguez S, Dharmaraj T, Chang T, et al.
J Clin Invest
. 2025 Mar;
135(5).
PMID: 40026251
Bacteriophage (phage) therapy has emerged as a promising solution to combat the growing crisis of multidrug-resistant (MDR) infections. There are several international centers actively engaged in implementation of phage therapy,...
2.
Echterhof A, Dharmaraj T, Blankenberg P, Hajfathalian M, Blankenberg F, Sacher J, et al.
bioRxiv
. 2025 Feb;
PMID: 39975350
Bacteriophages, viruses that selectively infect bacteria, are increasingly explored as potential therapies to combat antibiotic-resistant infections. Effective phage purification is vital for therapeutic use, particularly to reduce endotoxin (lipopolysaccharide, LPS)...
3.
Whole-body Bacteriophage Distribution Characterized by a Physiologically based Pharmacokinetic Model
Echterhof A, Dharmaraj T, Blankenberg P, Targ B, Bollyky P, Smith N, et al.
bioRxiv
. 2025 Feb;
PMID: 39975270
In 2019 there were over 2.8 million cases of antibiotic-resistant bacterial infection in the US with gram negative organisms having up to a 6% rate of mortality. Bacteriophage (phage) therapy...
4.
Echterhof A, Dharmaraj T, Khosravi A, McBride R, Miesel L, Chia J, et al.
JCI Insight
. 2024 Oct;
9(20).
PMID: 39435664
With the increasing prevalence of antimicrobial-resistant bacterial infections, there is interest in using bacteriophages (phages) to treat such infections. However, the factors that govern bacteriophage pharmacokinetics in vivo remain poorly...
5.
Lin Y, Dharmaraj T, Chen Q, Echterhof A, Manasherob R, Zhang L, et al.
bioRxiv
. 2024 May;
PMID: 38766200
Lytic bacteriophages, viruses that lyse (kill) bacteria, hold great promise for treating infections, including wound infections caused by antimicrobial-resistant However, the optimal dosing and delivery strategies for phage therapy remain...
6.
Echterhof A, Dharmaraj T, McBride R, Berry J, Hopkins M, Selvakumar H, et al.
bioRxiv
. 2024 Feb;
PMID: 38328123
With the increasing prevalence of antimicrobial-resistant bacterial infections, there is great interest in using lytic bacteriophages (phages) to treat such infections. However, the factors that govern bacteriophage pharmacokinetics remain poorly...
7.
Dharmaraj T, Kratochvil M, Pourtois J, Chen Q, Hajfathalian M, Hargil A, et al.
PNAS Nexus
. 2023 Dec;
2(12):pgad406.
PMID: 38111822
Extensive efforts are underway to develop bacteriophages as therapies against antibiotic-resistant bacteria. However, these efforts are confounded by the instability of phage preparations and a lack of suitable tools to...
8.
Elzamzami F, Samal A, Arun A, Dharmaraj T, Prasad N, Rendon-Jonguitud A, et al.
Front Cell Dev Biol
. 2023 Nov;
11:1240285.
PMID: 37936983
Clinical frailty affects ∼10% of people over age 65 and is studied in a chronically inflamed (Interleukin-10 knockout; "IL10-KO") mouse model. Frailty phenotypes overlap the spectrum of diseases ("laminopathies") caused...
9.
Dharmaraj T, Kratochvil M, Pourtois J, Chen Q, Hajfathalian M, Hargil A, et al.
bioRxiv
. 2023 Jul;
PMID: 37425882
Extensive efforts are underway to develop bacteriophages as therapies against antibiotic-resistant bacteria. However, these efforts are confounded by the instability of phage preparations and a lack of suitable tools to...
10.
Chen Q, Dharmaraj T, Cai P, Burgener E, Haddock N, Spakowitz A, et al.
Pharmaceutics
. 2022 Jul;
14(7).
PMID: 35890320
Bacteriophages, viruses that infect and replicate within bacteria, impact bacterial responses to antibiotics in complex ways. Recent studies using lytic bacteriophages to treat bacterial infections (phage therapy) demonstrate that phages...