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Teijo Pellinen

Explore the profile of Teijo Pellinen including associated specialties, affiliations and a list of published articles. Areas
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Articles 68
Citations 2147
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Recent Articles
1.
Heiskanen L, Nissinen L, Siljamaki E, Knuutila J, Pellinen T, Kallajoki M, et al.
Am J Pathol . 2025 Mar; PMID: 40056975
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, and the metastatic disease is associated with poor prognosis. Here, the role of complement C5a receptor, C5aR1, was...
2.
Block M, Clubb J, Maenpaa J, Pakola S, Quixabeira D, Kudling T, et al.
Nat Commun . 2025 Feb; 16(1):1381. PMID: 39910037
Immune checkpoint inhibitors have demonstrated modest efficacy as a monotherapy in ovarian cancer. Originally developed to improve efficacy of T-cell therapies such as immune checkpoint inhibitors and adoptive cell transfer,...
3.
Pakola S, Clubb J, Kudling T, van der Heijden M, Jirovec E, Arias V, et al.
J Immunother Cancer . 2025 Jan; 13(1). PMID: 39870491
Background: Oncolytic viruses (OVs) are promising immunotherapeutics to treat immunologically cold tumors. However, research on the mechanism of action of OVs in humans and clinically relevant biomarkers is still sparse....
4.
Autio M, Bruck O, Pollari M, Karjalainen-Lindsberg M, Beiske K, Jorgensen J, et al.
Haematologica . 2024 Dec; PMID: 39665214
The tumor microenvironments (TME) of diffuse large B-cell lymphoma (DLBCL) subgroups have remained poorly characterized. Here, we dissected the composition and spatial organization of the TME in germinal center B-cell...
5.
Punovuori K, Bertillot F, Miroshnikova Y, Binner M, Myllymaki S, Follain G, et al.
Cell . 2024 Oct; 187(25):7267-7284.e20. PMID: 39471809
Epithelial tumors are characterized by abundant inter- and intra-tumor heterogeneity, which complicates diagnostics and treatment. The contribution of cancer-stroma interactions to this heterogeneity is poorly understood. Here, we report a...
6.
Roos-Mattila M, Kallio P, Luck T, Polso M, Kumari R, Mikkonen P, et al.
Commun Biol . 2024 Oct; 7(1):1355. PMID: 39427059
Clear-cell renal cell carcinoma (ccRCC) is the most common origin of pancreatic metastases (PM). Distinct genomic aberrations, favorable prognosis, and clinical observations on high angiogenesis, and succeeding tyrosine kinase inhibitor...
7.
Feodoroff M, Hamdan F, Antignani G, Feola S, Fusciello M, Russo S, et al.
Oncoimmunology . 2024 Oct; 13(1):2407532. PMID: 39351443
Immunotherapy has emerged as a promising approach for cancer treatment, with oncolytic adenoviruses showing power as immunotherapeutic agents. In this study, we investigated the immunotherapeutic potential of an adenovirus construct...
8.
Knuutila J, Riihila P, Nissinen L, Heiskanen L, Kallionpaa R, Pellinen T, et al.
Int J Cancer . 2024 Apr; 155(6):1112-1127. PMID: 38648387
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer and the metastatic disease is associated with poor prognosis. Cancer-associated fibroblasts (CAFs) promote progression of cancer, but their...
9.
Russo S, Feola S, Feodoroff M, Chiaro J, Antignani G, Fusciello M, et al.
Mol Ther Oncol . 2024 Apr; 32(1):200766. PMID: 38596301
Cancer immunotherapy requires a specific antitumor CD8 T cell-driven immune response; however, upon genetic and epigenetic alterations of the antigen processing and presenting components, cancer cells escape the CD8 T ...
10.
Pakola S, Peltola K, Clubb J, Jirovec E, Haybout L, Kudling T, et al.
Clin Cancer Res . 2024 Mar; 30(17):3715-3725. PMID: 38546220
Purpose: TILT-123 (igrelimogene litadenorepvec) is an oncolytic adenovirus armed with TNFa and IL2, designed to induce T-cell infiltration and cytotoxicity in solid tumors. Patients And Methods: TUNIMO (NCT04695327) was a...