Teemu Heikkila
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Explore the profile of Teemu Heikkila including associated specialties, affiliations and a list of published articles.
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14
Citations
186
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Recent Articles
1.
Liu P, De Wulf O, Laru J, Heikkila T, van Veen B, Kiesvaara J, et al.
AAPS PharmSciTech
. 2013 Apr;
14(2):748-56.
PMID: 23615772
Sink conditions used in dissolution tests lead to rapid dissolution rates for nanosuspensions, causing difficulties in discriminating dissolution profiles between different formulations. Here, non-sink conditions were studied for the dissolution...
2.
Keshvari J, Heikkila T
Prog Biophys Mol Biol
. 2011 Oct;
107(3):439-42.
PMID: 22005524
Previous studies comparing SAR difference in the head of children and adults used highly simplified generic models or half-wave dipole antennas. The objective of this study was to investigate the...
3.
Sarparanta M, Makila E, Heikkila T, Salonen J, Kukk E, Lehto V, et al.
Mol Pharm
. 2011 Aug;
8(5):1799-806.
PMID: 21875120
Because of its biocompatibility and ability to accommodate a variety of payloads from poorly soluble drugs to biomolecules, porous silicon (PSi) is a lucrative material for the development of carriers...
4.
Limnell T, Heikkila T, Santos H, Sistonen S, Hellsten S, Laaksonen T, et al.
Int J Pharm
. 2011 Jul;
416(1):242-51.
PMID: 21763766
Stability of high indomethacin (IMC) content formulations based on ordered mesoporous silica MCM-41 and SBA-15 materials was studied before and after a 3 month storage in stressed conditions (30°C/56% RH)....
5.
Kinnari P, Makila E, Heikkila T, Salonen J, Hirvonen J, Santos H
Int J Pharm
. 2011 May;
414(1-2):148-56.
PMID: 21601623
Mesoporous materials have an ability to enhance dissolution properties of poorly soluble drugs. In this study, different mesoporous silicon (thermally oxidized and thermally carbonized) and non-ordered mesoporous silica (Syloid AL-1...
6.
Limnell T, Santos H, Makila E, Heikkila T, Salonen J, Murzin D, et al.
J Pharm Sci
. 2011 Apr;
100(8):3294-3306.
PMID: 21520084
A poorly soluble model drug, indomethacin (IMC), was loaded into two types of silica particles using three different loading methods. The loading efficiency and the extent/rate of drug release were...
7.
Maki-Arvela P, Tokarev A, Murzina E, Campo B, Heikkila T, Brozinski J, et al.
Phys Chem Chem Phys
. 2011 Apr;
13(20):9268-80.
PMID: 21475770
Several mono- and bimetallic Pd, Pt, Rh and Ru supported on alumina and active carbon catalysts were characterized by CO chemisorption, nitrogen adsorption, XPS and XRD and acidity titrations were...
8.
Santos H, Riikonen J, Salonen J, Makila E, Heikkila T, Laaksonen T, et al.
Acta Biomater
. 2009 Dec;
6(7):2721-31.
PMID: 20036766
We report here the in vitro cytotoxicity of mesoporous silicon (PSi) microparticles on the Caco-2 cells as a function of particle size fractions (1.2-75 microm), particle concentration (0.2-4 mg ml(-1))...
9.
Heikkila T, Santos H, Kumar N, Murzin D, Salonen J, Laaksonen T, et al.
Eur J Pharm Biopharm
. 2009 Dec;
74(3):483-94.
PMID: 20025968
Cytotoxicity of ordered mesoporous silica MCM-41 and SBA-15 microparticles (fractions between 1 and 160 microm) was determined in vitro on undifferentiated human colon carcinoma (Caco-2) cell line, considering the feasibility...
10.
Laaksonen T, Santos H, Vihola H, Salonen J, Riikonen J, Heikkila T, et al.
Chem Res Toxicol
. 2007 Nov;
20(12):1913-8.
PMID: 17990852
In this work, it is shown that the common toxicity indicator, MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide), will fail to predict the toxicity of porous silicon (PSi) microparticles. This is due to the...