Tayler J Croom-Perez
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Explore the profile of Tayler J Croom-Perez including associated specialties, affiliations and a list of published articles.
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16
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87
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Recent Articles
1.
Lu H, Wise S, Toyoda J, Speer R, Croom-Perez T, Meaza I, et al.
Chemosphere
. 2024 Dec;
370():143982.
PMID: 39701314
Lung cancer is an important human health concern because of its high mortality rate, with many cases caused by environmental chemicals other than tobacco. Particulate hexavalent chromium [Cr(VI)] is a...
2.
Lu H, Wise S, Speer R, Croom-Perez T, Toyoda J, Meaza I, et al.
Toxicol Sci
. 2024 Jun;
201(1):1-13.
PMID: 38867691
Hexavalent chromium [Cr(VI)] is an established human lung carcinogen, but the carcinogenesis mechanism is poorly understood. Chromosome instability, a hallmark of lung cancer, is considered a major driver of Cr(VI)-induced...
3.
Oyer J, Croom-Perez T, Hasan M, Rivera-Huertas J, Gitto S, Mucha J, et al.
Front Immunol
. 2024 May;
15:1383281.
PMID: 38711506
NK cell therapeutics have gained significant attention as a potential cancer treatment. Towards therapeutic use, NK cells need to be activated and expanded to attain high potency and large quantities...
4.
Lu H, Toyoda J, Wise S, Browning C, Speer R, Croom-Perez T, et al.
Toxicol Sci
. 2024 Mar;
199(1):49-62.
PMID: 38539048
Chromosome instability, a hallmark of lung cancer, is a driving mechanism for hexavalent chromium [Cr(VI)] carcinogenesis in humans. Cr(VI) induces structural and numerical chromosome instability in human lung cells by...
5.
Hasan M, Campbell A, Croom-Perez T, Oyer J, Dieffenthaller T, Robles-Carrillo L, et al.
J Immunother Cancer
. 2023 Dec;
11(12).
PMID: 38081778
Background: Inhibitory receptor T-cell Immunoreceptor with Ig and ITIM domains (TIGIT) expressed by Natural Killer (NK) and T cells regulates cancer immunity and has been touted as the next frontier...
6.
Meaza I, Williams A, Lu H, Kouokam J, Toyoda J, Croom-Perez T, et al.
Toxicol Appl Pharmacol
. 2023 Oct;
479:116711.
PMID: 37805091
Hexavalent chromium [Cr(VI)] is a human lung carcinogen with widespread exposure risks. Cr(VI) causes DNA double strand breaks that if unrepaired, progress into chromosomal instability (CIN), a key driving outcome...
7.
Croom-Perez T, Robles-Carillo L, Oyer J, Dieffenthaller T, Hasan M, Copik A
Methods Cell Biol
. 2023 Jul;
178:63-91.
PMID: 37516529
Natural Killer cells (NK cells) are a key component of the innate immune system and are key effectors of immunosurveillance. NK cells not only have the inherent ability to directly...
8.
Hasan M, Croom-Perez T, Oyer J, Dieffenthaller T, Robles-Carrillo L, Eloriaga J, et al.
Cancers (Basel)
. 2023 Jun;
15(10).
PMID: 37345049
Treatments targeting TIGIT have gained a lot of attention due to strong preclinical and early clinical results, particularly with anti-PD-(L)1 therapeutics. However, this combination has failed to meet progression-free survival...
9.
Wise S, Lu H, Speer R, Wise Jr J, Young J, Toyoda J, et al.
Toxicol Appl Pharmacol
. 2022 Oct;
457:116294.
PMID: 36283442
Hexavalent chromium [Cr(VI)] is a well-known and widespread environmental contaminant associated with a variety of adverse health effects, in particular lung cancer. The primary route of exposure in humans is...
10.
Oyer J, Croom-Perez T, Dieffenthaller T, Robles-Carillo L, Gitto S, Altomare D, et al.
Front Immunol
. 2022 Apr;
13:861681.
PMID: 35464440
There is a great interest in developing natural killer (NK) cells as adoptive cancer immunotherapy. For off-the-shelf approaches and to conduct multicenter clinical trials, cryopreserved NK cells are the preferred...