Tatyana A Grigoreva
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Explore the profile of Tatyana A Grigoreva including associated specialties, affiliations and a list of published articles.
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11
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82
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Recent Articles
1.
Grigoreva T, Kindt D, Sagaidak A, Novikova D, Tribulovich V
Cells
. 2025 Feb;
14(3).
PMID: 39936962
Oncological diseases consistently occupy leading positions among the most life-threatening diseases, including in highly developed countries. At the same time, the second most common cause of cancer death is colorectal...
2.
Grigoreva T, Sagaidak A, Novikova D, Tribulovich V
Arch Biochem Biophys
. 2024 Dec;
764():110258.
PMID: 39638141
P-glycoprotein (P-gp) plays an important role in the rapid release of various small molecule substances from the cell. In turn, inhibition of this efflux transporter is an attractive strategy for...
3.
Grigoreva T, Vorona S, Novikova D, Tribulovich V
ACS Omega
. 2024 Aug;
9(30):33000-33010.
PMID: 39100288
The use of viral protein inhibitors has shown to be insufficiently effective in the case of highly variable SARS-CoV-2. In this work, we examined the possibility of designing agents that...
4.
Grigoreva T, Novikova D, Melino G, Barlev N, Tribulovich V
Biol Direct
. 2024 Jul;
19(1):55.
PMID: 38978100
Ubiquitinylation of protein substrates results in various but distinct biological consequences, among which ubiquitin-mediated degradation is most well studied for its therapeutic application. Accordingly, artificially targeted ubiquitin-dependent degradation of various...
5.
Grigoreva T, Sagaidak A, Vorona S, Novikova D, Tribulovich V
ACS Med Chem Lett
. 2022 Dec;
13(12):1848-1855.
PMID: 36518704
Since the problem of transporter-mediated multidrug resistance of tumor cells is becoming increasingly important in cancer therapy, it is necessary to modulate the activity of efflux transporters of the ABC...
6.
Grigoreva T, Vorona S, Novikova D, Tribulovich V
ACS Omega
. 2022 Dec;
7(47):42835-42844.
PMID: 36467933
P-glycoprotein (P-gp) is found to be of considerable interest for the design of drugs capable of treating chemoresistant tumors. This transporter is an interesting target for which an efficient approach...
7.
Grigoreva T, Sagaidak A, Novikova D, Tribulovich V
Eur J Pharmacol
. 2022 Oct;
935:175327.
PMID: 36265610
ABC transporters play an essential role in the development of multidrug resistance and thus are of interest in the context of anticancer therapy. However, MDR1, BCRP and MRP1 are involved...
8.
Novikova D, Grigoreva T, Zolotarev A, Garabadzhiu A, Tribulovich V
RSC Adv
. 2022 May;
8(60):34543-34551.
PMID: 35548634
A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed...
9.
Novikova D, Grigoreva T, Ivanov G, Melino G, Barlev N, Tribulovich V
ChemMedChem
. 2020 Aug;
15(24):2521-2529.
PMID: 32762073
AMP-activated protein kinase (AMPK) is currently the subject of intensive study and active discussions. AMPK performs its functions both at the cellular level, providing the switch between energy-consuming and energy-producing...
10.
Grigoreva T, Novikova D, Gureev M, Garabadzhiu A, Tribulovich V
Chirality
. 2018 Mar;
30(6):785-797.
PMID: 29575058
The absolute configurations of the diastereomers of novel amino acid ester derivatives of 2,3-substituted isoindolinones, which are known as apoptosis activators due to their ability to inhibit the MDM2-p53 PPI,...