Tatiana L Fonseca
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Explore the profile of Tatiana L Fonseca including associated specialties, affiliations and a list of published articles.
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36
Citations
901
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Recent Articles
1.
Batistuzzo A, Zhang X, Bocco B, McAninch E, Salas-Lucia F, Ribeiro M, et al.
Endocrinology
. 2025 Mar;
PMID: 40085762
The Thr92Ala-Dio2 polymorphism is prevalent worldwide, with about 50% of the population carrying at least one allele. The Ala92-Dio2 allele encodes a less active D2 enzyme and has been associated...
2.
Sinko R, Salas-Lucia F, Mohacsik P, Halmos E, Wittmann G, Egri P, et al.
Proc Natl Acad Sci U S A
. 2025 Feb;
122(6):e2415970122.
PMID: 39903117
L-thyroxine (L-T4) monotherapy is the standard treatment for hypothyroidism, administered daily to normalize TSH levels. Once absorbed, T4 is converted to T3 to alleviate most symptoms. However, this treatment abnormally...
3.
Hidalgo-Alvarez J, Fonseca T, Salas-Lucia F, Bianco A
J Vis Exp
. 2024 Dec;
(214).
PMID: 39714036
Obtaining stable hepatic cells in culture poses a significant challenge for liver studies. Bearing this in mind, an optimized method is depicted utilizing human induced pluripotent stem cells (hiPSCs) to...
4.
Gabriel de Almeida G, Bolin A, Batistuzzo A, Fonseca T, Ribeiro M, Bianco A
Endocrinology
. 2024 Jun;
165(7).
PMID: 38836615
About half of the world population carries at least one allele of the Ala92-DIO2, which slows down the activity of the type 2 deiodinase (D2), the enzyme that activates T4...
5.
Hidalgo-Alvarez J, Salas-Lucia F, Vera Cruz D, Fonseca T, Bianco A
JCI Insight
. 2023 Oct;
8(23).
PMID: 37856222
Thyroid hormone (TH) levels are low during development, and the deiodinases control TH signaling through tissue-specific activation or inactivation of TH. Here, we studied human induced pluripotent stem cell-derived (iPSC-derived)...
6.
Sinko R, Mohacsik P, Kovari D, Penksza V, Wittmann G, Macsai L, et al.
Thyroid
. 2022 Nov;
33(1):109-118.
PMID: 36322711
Non-Thyroidal Illness Syndrome (NTIS) caused by infection or fasting is hallmarked by reduced circulating thyroid hormone (TH) levels. To better understand the role of local TH-action in the development of...
7.
Zaccarelli-Magalhaes J, Abreu G, Fukushima A, Pantaleon L, Ribeiro B, Munhoz C, et al.
Behav Brain Res
. 2022 Aug;
436:114082.
PMID: 36041571
Postpartum depression is a mentally disabling disease with multifactorial etiology that affects women worldwide. It can also influence child development and lead to behavioral and cognitive alterations. Despite the high...
8.
Ahmed Z, Sherin R, Fonseca T, Hoang T, Shakir M
Clin Case Rep
. 2022 Apr;
10(4):e05651.
PMID: 35432999
We report a 54-year-old man with treatment-resistant depression (TRD) and hypothyroidism who responded to LT3/LT4 combination, rather than LT4 alone. He was able to discontinue all antidepressant medications eventually. Interestingly,...
9.
Fonseca T, Russo S, Luongo C, Salvatore D, Bianco A
Endocrinology
. 2022 Mar;
163(5).
PMID: 35238380
Adaptive thermogenesis in small mammals and infants takes place in brown adipose tissue (BAT). Heat is produced via uncoupling protein 1 (UCP1)-mediated uncoupling between oxidation of energy substrates and adenosine...
10.
Fonseca T, Garcia T, Fernandes G, Nair T, Bianco A
Nat Commun
. 2021 Jul;
12(1):4446.
PMID: 34290257
The type 2 deiodinase (D2) in the neonatal liver accelerates local thyroid hormone triiodothyronine (T3) production and expression of T3-responsive genes. Here we show that this surge in T3 permanently...