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Tarsila Barros Moraes

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Articles 12
Citations 137
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Recent Articles
1.
Wayhs C, Mescka C, Guerreiro G, Moraes T, Jacques C, Rosa A, et al.
Cell Biochem Funct . 2014 Nov; 32(8):711-9. PMID: 25431174
There is increasing evidence suggesting that oxidative stress plays an important role in the development of many chronic and degenerative conditions such as diabetic encephalopathy and depression. Considering that diabetic...
2.
Moraes T, Dalazen G, Jacques C, de Freitas R, Rosa A, Dutra-Filho C
Metab Brain Dis . 2014 Feb; 29(3):609-15. PMID: 24488205
Phenylketonuria (PKU) is a disorder caused by a deficiency in phenylalanine hydroxylase activity, which converts phenylalanine (Phe) to tyrosine, leading to hyperphenylalaninemia (HPA) with accumulation of Phe in tissues of...
3.
Moraes T, Jacques C, Rosa A, Dalazen G, Terra M, Coelho J, et al.
Cell Mol Neurobiol . 2012 Dec; 33(2):253-60. PMID: 23232760
Phenylketonuria (PKU) is an inherited metabolic disorder caused by deficiency of phenylalanine hydroxylase which leads to accumulation of phenylalanine and its metabolites in tissues of patients with severe neurological involvement....
4.
Rosa A, Jacques C, Moraes T, Wannmacher C, Dutra A, Dutra-Filho C
Cell Mol Neurobiol . 2012 Apr; 32(7):1113-8. PMID: 22477023
Phenylketonuria is a recessive autosomal disorder that is caused by a deficiency in the activity of phenylalanine-4-hydroxylase, which converts phenylalanine to tyrosine, leading to the accumulation of phenylalanine and its...
5.
Berti S, Nasi G, Garcia C, de Castro F, Nunes M, Rojas D, et al.
Metab Brain Dis . 2011 Nov; 27(1):79-89. PMID: 22101931
Phenylketonuria is characterized by a variable degree of mental retardation and other neurological features whose mechanisms are not fully understood. In the present study we investigated the effect of intrahippocampal...
6.
Mazzola P, Terra M, Rosa A, Mescka C, Moraes T, Piccoli B, et al.
Metab Brain Dis . 2011 Sep; 26(4):291-7. PMID: 21947687
Phenylketonuria (PKU) is caused by deficiency of phenylalanine hydroxylase, leading to accumulation of phenylalanine and its metabolites. Clinical features of PKU patients include mental retardation, microcephaly, and seizures. Oxidative stress...
7.
Jacob M, Janner D, Araujo A, Jahn M, Kucharski L, Moraes T, et al.
J Steroid Biochem Mol Biol . 2011 Aug; 127(3-5):331-6. PMID: 21831349
This study examined, in the liver of young and old (3- and 24-month-old, respectively) healthy Wistar rats, the in vivo effect of dehydroepiandrosterone (DHEA) (10mg/kg body weight) administered subcutaneously for...
8.
Jacob M, Janner D, Araujo A, Jahn M, Kucharski L, Moraes T, et al.
Exp Gerontol . 2010 Sep; 45(12):957-63. PMID: 20832465
This study examined, in young and old (3 and 24 month-old, respectively) healthy Wistar rats, the in vivo effect of DHEA (10 mg/kg body weight) administered subcutaneously for 5 weeks....
9.
Pederzolli C, Rosa A, de Oliveira A, Coelho J, da Luz Becker D, Dalazen G, et al.
Mol Cell Biochem . 2010 Aug; 344(1-2):231-9. PMID: 20686917
N-Acetylaspartic acid (NAA) accumulates in Canavan disease, a severe inherited neurometabolic disorder clinically characterized by mental retardation, hypotonia, macrocephaly, and seizures. The mechanisms of brain damage in this disease remain...
10.
Moraes T, Zanin F, da Rosa A, de Oliveira A, Coelho J, Petrillo F, et al.
J Neurol Sci . 2010 Mar; 292(1-2):89-95. PMID: 20226470
Phenylketonuria (PKU) is a recessive autosomal disorder caused by a severe deficiency of phenylalanine-4-hydroxilase activity which leads to the accumulation of L-phenylalanine (Phe) in the tissues and plasma of patients....