Tara K Sigdel
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Explore the profile of Tara K Sigdel including associated specialties, affiliations and a list of published articles.
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74
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1564
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Recent Articles
1.
Sun Y, Sen S, Parmar R, Arakawa-Hoyt J, Cappelletti M, Rossetti M, et al.
Front Immunol
. 2025 Mar;
16:1542531.
PMID: 40028342
Introduction: Cytomegalovirus (CMV) viremia remains a major contributor to clinical complications in solid organ transplant (SOT) patients, including organ injury, morbidity and mortality. Given their critical role in antiviral defense,...
2.
Brown A, Kelly Y, Zarinsefat A, Meier R, Worner G, Tavakol M, et al.
Am J Transplant
. 2024 Sep;
25(2):316-328.
PMID: 39349170
Pancreas transplantation improves glycemic control and mortality in patients with diabetes but requires aggressive immunosuppression to control the alloimmune and autoimmune response. Recent developments in "omics" methods have provided gene...
3.
Sigdel T, Sur S, Boada P, McDermott S, Arlehamn C, Murray K, et al.
Inflammation
. 2023 Oct;
47(1):346-362.
PMID: 37831367
Infectious diseases are a significant burden in global healthcare. Pathogens engage with different host defense mechanisms. However, it is currently unknown if there are disease-specific immune signatures and/or if different...
4.
Lamarthee B, Callemeyn J, Van Herck Y, Antoranz A, Anglicheau D, Boada P, et al.
Nat Commun
. 2023 Jul;
14(1):4359.
PMID: 37468466
Rejection remains the main cause of premature graft loss after kidney transplantation, despite the use of potent immunosuppression. This highlights the need to better understand the composition and the cell-to-cell...
5.
Rashmi P, Sigdel T, Rychkov D, Damm I, da Silva A, Vincenti F, et al.
Ann Transl Med
. 2023 Jul;
11(9):315.
PMID: 37404982
Background: Focal segmental glomerulosclerosis (FSGS) is frequently associated with heavy proteinuria and progressive renal failure requiring dialysis or kidney transplantation. However, primary FSGS also has a ~40% risk of recurrence...
6.
Sigdel T, Boada P, Kerwin M, Rashmi P, Gjertson D, Rossetti M, et al.
PLoS One
. 2023 May;
18(5):e0285870.
PMID: 37205661
Background: Cytomegalovirus (CMV) infection, either de novo or as reactivation after allotransplantation and chronic immunosuppression, is recognized to cause detrimental alloimmune effects, inclusive of higher susceptibility to graft rejection and...
7.
Boada P, Fatou B, Belperron A, Sigdel T, Smolen K, Wurie Z, et al.
Front Immunol
. 2022 Dec;
13():1012824.
PMID: 36569838
Advancement in proteomics methods for interrogating biological samples has helped identify disease biomarkers for early diagnostics and unravel underlying molecular mechanisms of disease. Herein, we examined the serum proteomes of...
8.
Sigdel T, Fields P, Liberto J, Damm I, Kerwin M, Hood J, et al.
Front Immunol
. 2022 Dec;
13:1012042.
PMID: 36466928
In this cross-sectional and longitudinal analysis of mapping the T-cell repertoire in kidney transplant recipients, we have investigated and validated T-cell clonality, immune repertoire chronology at rejection, and contemporaneous allograft...
9.
Hansen J, Sealfon R, Menon R, Eadon M, Lake B, Steck B, et al.
Sci Adv
. 2022 Jun;
8(23):eabn4965.
PMID: 35675394
Kidney Precision Medicine Project (KPMP) is building a spatially specified human kidney tissue atlas in health and disease with single-cell resolution. Here, we describe the construction of an integrated reference...
10.
Sur S, Nguyen M, Boada P, Sigdel T, Sollinger H, Sarwal M
Front Immunol
. 2021 Dec;
12:769972.
PMID: 34925339
Diabetic kidney disease (DKD) is a key microvascular complication of diabetes, with few therapies for targeting renal disease pathogenesis and progression. We performed transcriptional and protein studies on 103 unique...