Tania M Puvirajesinghe
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Explore the profile of Tania M Puvirajesinghe including associated specialties, affiliations and a list of published articles.
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14
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205
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Recent Articles
1.
Walton A, Thome V, Revinski D, Marchetto S, Puvirajesinghe T, Audebert S, et al.
J Biol Chem
. 2024 Feb;
300(4):106792.
PMID: 38403249
First described in the milkweed bug Oncopeltus fasciatus, planar cell polarity (PCP) is a developmental process essential for embryogenesis and development of polarized structures in Metazoans. This signaling pathway involves...
2.
Daulat A, Puvirajesinghe T, Camoin L, Borg J
J Mol Biol
. 2018 May;
430(19):3545-3564.
PMID: 29782831
Cell polarity is a vital biological process involved in the building, maintenance and normal functioning of tissues in invertebrates and vertebrates. Unsurprisingly, molecular defects affecting polarity organization and functions have...
3.
Aznavourian R, Puvirajesinghe T, Brule S, Enoch S, Guenneau S
J Phys Condens Matter
. 2017 Jul;
29(43):433004.
PMID: 28742059
We begin with a brief historical survey of discoveries of quasi-crystals and graphene, and then introduce the concept of transformation crystallography, which consists of the application of geometric transforms to...
4.
Puvirajesinghe T, Turnbull J
Microarrays (Basel)
. 2016 Sep;
5(1).
PMID: 27600069
Microarray technologies inspired the development of carbohydrate arrays. Initially, carbohydrate array technology was hindered by the complex structures of glycans and their structural variability. The first designs of glycoarrays focused...
5.
Puvirajesinghe T, Bertucci F, Jain A, Scerbo P, Belotti E, Audebert S, et al.
Nat Commun
. 2016 Jan;
7:10318.
PMID: 26754771
The non-canonical Wnt/planar cell polarity (Wnt/PCP) pathway plays a crucial role in embryonic development. Recent work has linked defects of this pathway to breast cancer aggressiveness and proposed Wnt/PCP signalling...
6.
Kalus I, Rohn S, Puvirajesinghe T, Guimond S, Eyckerman-Kolln P, Ten Dam G, et al.
PLoS One
. 2015 Oct;
10(10):e0139853.
PMID: 26448642
Introduction: Sulf1 and Sulf2 are cell surface sulfatases, which remove specific 6-O-sulfate groups from heparan sulfate (HS) proteoglycans, resulting in modulation of various HS-dependent signaling pathways. Both Sulf1 and Sulf2...
7.
Puvirajesinghe T, Borg J
Metabolites
. 2015 Mar;
5(1):164-83.
PMID: 25789708
Neural tube defects (NTDs) are congenital birth defects classified according to their resulting morphological characteristics in newborn patients. Current diagnosis of NTDs relies largely on the structural evaluation of fetuses...
8.
Puvirajesinghe T, Turnbull J
Metabolites
. 2014 Jun;
2(4):1060-89.
PMID: 24957775
The glycosaminoglycan heparan sulphate (HS) has a heterogeneous structure; evidence shows that specific structures may be responsible for specific functions in biological processes such as blood coagulation and regulation of...
9.
Belotti E, Puvirajesinghe T, Audebert S, Baudelet E, Camoin L, Pierres M, et al.
PLoS One
. 2012 Oct;
7(9):e46213.
PMID: 23029439
Background: Mutations in the Planar Cell Polarity (PCP) core gene Vangl2 cause the most severe neural tube defects (NTD) in mice and humans. Genetic studies show that the Vangl2 gene...
10.
Puvirajesinghe T, Ahmed Y, Powell A, Fernig D, Guimond S, Turnbull J
Chem Biol
. 2012 May;
19(5):553-8.
PMID: 22633407
Array methodologies have become powerful tools for interrogation of glycan-protein interactions but have critically lacked the ability to generate cell response data. Here, we report the development of a slide-based...