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Tamas Hezso

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Articles 10
Citations 92
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Recent Articles
1.
Kovacs Z, Horvath B, Dienes C, Ovari J, Kiss D, Hezso T, et al.
Int J Mol Sci . 2024 Nov; 25(21). PMID: 39519160
Several ion currents in the mammalian ventricular myocardium are substantially regulated by the sympathetic nervous system via β-adrenergic receptor activation, including the slow delayed rectifier K current and the L-type...
2.
Kovacs Z, Dienes C, Hezso T, Almassy J, Magyar J, Banyasz T, et al.
Pharmaceuticals (Basel) . 2022 Jan; 15(1). PMID: 35056138
Transient receptor potential melastatin 4 is a unique member of the TRPM protein family and, similarly to TRPM5, is Ca-sensitive and permeable to monovalent but not divalent cations. It is...
3.
Dienes C, Kovacs Z, Hezso T, Almassy J, Magyar J, Banyasz T, et al.
Pharmaceuticals (Basel) . 2022 Jan; 15(1). PMID: 35056097
Transient receptor potential melastatin 4 (TRPM4) is a unique member of the TRPM protein family and, similarly to TRPM5, is Ca sensitive and permeable for monovalent but not divalent cations....
4.
Kiss D, Horvath B, Hezso T, Dienes C, Kovacs Z, Topal L, et al.
Pharmaceuticals (Basel) . 2021 Nov; 14(11). PMID: 34832924
Enhancement of the late sodium current (I) increases arrhythmia propensity in the heart, whereas suppression of the current is antiarrhythmic. In the present study, we investigated I in canine ventricular...
5.
Dienes C, Hezso T, Kiss D, Baranyai D, Kovacs Z, Szabo L, et al.
Int J Mol Sci . 2021 Sep; 22(17). PMID: 34502410
Transient receptor potential melastatin 4 (TRPM4) plays an important role in many tissues, including pacemaker and conductive tissues of the heart, but much less is known about its electrophysiological role...
6.
Horvath B, Kiss D, Dienes C, Hezso T, Kovacs Z, Szentandrassy N, et al.
J Mol Cell Cardiol . 2021 Jun; 158:153-162. PMID: 34089737
The profiles of ion currents during the cardiac action potential can be visualized by the action potential voltage clamp technique. To obtain multiple ion current data from the same cell,...
7.
Hezso T, Naveed M, Dienes C, Kiss D, Prorok J, Arpadffy-Lovas T, et al.
Sci Rep . 2021 May; 11(1):9565. PMID: 33953276
Enhancement of the late Na current (I) increases arrhythmia propensity in the heart, while suppression of the current is antiarrhythmic. GS967 is an agent considered as a selective blocker of...
8.
Kistamas K, Hezso T, Horvath B, Nanasi P
Channels (Austin) . 2020 Dec; 15(1):1-19. PMID: 33258400
The cardiac late sodium current (I) is the small sustained component of the sodium current active during the plateau phase of the action potential. Several studies demonstrated that augmentation of...
9.
Horvath B, Hezso T, Kiss D, Kistamas K, Magyar J, Nanasi P, et al.
Front Pharmacol . 2020 May; 11:413. PMID: 32372952
Based on recent findings, an increased late sodium current (I) plays an important pathophysiological role in cardiac diseases, including rhythm disorders. The article first describes what is I and how...
10.
Horvath B, Hezso T, Szentandrassy N, Kistamas K, Arpadffy-Lovas T, Varga R, et al.
J Mol Cell Cardiol . 2020 Jan; 139:14-23. PMID: 31958464
Although late sodium current (I) has long been known to contribute to plateau formation of mammalian cardiac action potentials, lately it was considered as possible target for antiarrhythmic drugs. However,...