Tamara Hermosilla
Overview
Explore the profile of Tamara Hermosilla including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
292
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0
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Recent Articles
1.
Diaz-Garcia A, Garrido A, Ruiz-Fuentes J, Hermosilla T, Varela D
J Venom Anim Toxins Incl Trop Dis
. 2025 Feb;
31:e20240035.
PMID: 39906356
Background: Non-small cell lung cancers (NSCLC) represent the primary cause of cancer-related deaths worldwide. venom has been shown to exert cytotoxic effects against a panel of epithelial cancer cells and...
2.
Arancibia F, De Giorgis D, Medina F, Hermosilla T, Simon F, Varela D
Channels (Austin)
. 2024 May;
18(1):2338782.
PMID: 38691022
L-type calcium channels are essential for the excitation-contraction coupling in cardiac muscle. The Ca1.2 channel is the most predominant isoform in the ventricle which consists of a multi-subunit membrane complex...
3.
Ca1.2 Activity and Downstream Signaling Pathways in the Hippocampus of An Animal Model of Depression
Moreno C, Hermosilla T, Hardy P, Aballai V, Rojas P, Varela D
Cells
. 2020 Dec;
9(12).
PMID: 33291797
Functional and morphological modifications in the brain caused by major mood disorders involve many brain areas, including the hippocampus, leading to cognitive and mood alterations. Ca1.2 channel expression has been...
4.
Morales D, Hermosilla T, Varela D
J Gen Physiol
. 2019 Mar;
151(6):786-797.
PMID: 30814137
The activity of L-type calcium channels is associated with the duration of the plateau phase of the cardiac action potential (AP) and it is controlled by voltage- and calcium-dependent inactivation...
5.
Hermosilla T, Encina M, Morales D, Moreno C, Conejeros C, Alfaro-Valdes H, et al.
Sci Rep
. 2017 Sep;
7(1):10131.
PMID: 28860469
The cardiac L-type calcium channel is a multi-subunit complex that requires co-assembling of the pore-forming subunit Ca1.2 with auxiliary subunits Caαδ and Caβ. Its traffic has been shown to be...
6.
Moreno C, Hermosilla T, Morales D, Encina M, Torres-Diaz L, Diaz P, et al.
Pflugers Arch
. 2015 Aug;
467(12):2473-84.
PMID: 26265381
In the heart, the main pathway for calcium influx is mediated by L-type calcium channels, a multi-subunit complex composed of the pore-forming subunit CaV1.2 and the auxiliary subunits CaVα2δ1 and...
7.
Echeverria C, Montorfano I, Hermosilla T, Armisen R, Velasquez L, Cabello-Verrugio C, et al.
PLoS One
. 2014 Apr;
9(4):e94146.
PMID: 24710004
The pathogenesis of systemic inflammatory diseases, including endotoxemia-derived sepsis syndrome, is characterized by endothelial dysfunction. It has been demonstrated that the endotoxin lipopolysaccharide (LPS) induces the conversion of endothelial cells...
8.
Hermosilla T, Moreno C, Itfinca M, Altier C, Armisen R, Stutzin A, et al.
Channels (Austin)
. 2011 Apr;
5(3):280-6.
PMID: 21525790
Angiotensin II regulation of L-type calcium currents in cardiac muscle is controversial and the underlying signaling events are not completely understood. Moreover, the possible role of auxiliary subunit composition of...
9.
Altier C, Garcia-Caballero A, Simms B, You H, Chen L, Walcher J, et al.
Nat Neurosci
. 2010 Dec;
14(2):173-80.
PMID: 21186355
It is well established that the auxiliary Cavβ subunit regulates calcium channel density in the plasma membrane, but the cellular mechanism by which this occurs has remained unclear. We found...
10.
McRory J, Rehak R, Simms B, Doering C, Chen L, Hermosilla T, et al.
Biochem Biophys Res Commun
. 2008 Aug;
375(3):372-7.
PMID: 18713622
We have generated a syntaxin 1A knockout mouse by deletion of exons 3 through 6 and a concomitant insertion of a stop codon in exon 2. Heterozygous knockout animals were...