Tamar Getter
Overview
Explore the profile of Tamar Getter including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
106
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Recent Articles
1.
Hussein W, Goldberg D, Tenzer G, Bentwich I, Haran Y, Getter T
ACS Omega
. 2024 Nov;
9(44):44214-44223.
PMID: 39524682
Liver 3D cell models are regularly employed as a screening platform for predicting the metabolic safety of drugs, by monitoring the physiological responses of the spheroids, through the measurement of...
2.
Chen S, Getter T, Salom D, Wu D, Quetschlich D, Chorev D, et al.
Nature
. 2022 Apr;
604(7905):384-390.
PMID: 35388214
G protein-coupled receptors (GPCRs) are cell-surface receptors that respond to various stimuli to induce signalling pathways across cell membranes. Recent progress has yielded atomic structures of key intermediates and roles...
3.
Getter T, Kemp A, Vinberg F, Palczewski K
J Biol Chem
. 2021 Nov;
297(6):101401.
PMID: 34774799
The elongated cilia of the outer segment of rod and cone photoreceptor cells can contain concentrations of visual pigments of up to 5 mM. The rod visual pigments, G protein-coupled...
4.
Blum E, Margalit R, Levy L, Getter T, Lahav R, Zilber S, et al.
Molecules
. 2021 Aug;
26(15).
PMID: 34361736
We recently developed a molecule (GT-73) that blocked leukocyte transendothelial migration from blood to the peripheral tissues, supposedly by affecting the platelet endothelial cell adhesion molecule (PECAM-1) function. GT-73 was...
5.
Getter T, Margalit R, Kahremany S, Levy L, Blum E, Khazanov N, et al.
Bioorg Chem
. 2019 Oct;
92:103250.
PMID: 31580982
Leukocyte transendothelial migration is one of the most important step in launching an inflammatory immune response and chronic inflammation can lead to devastating diseases. Leukocyte migration inhibitors are considered as...
6.
Getter T, Gulati S, Zimmerman R, Chen Y, Vinberg F, Palczewski K
FASEB J
. 2019 May;
33(8):9526-9539.
PMID: 31121099
The classic concept that GPCRs function as monomers has been challenged by the emerging evidence of GPCR dimerization and oligomerization. Rhodopsin (Rh) is the only GPCR whose native oligomeric arrangement...
7.
Getter T, Suh S, Hoang T, Handa J, Dong Z, Ma X, et al.
J Biol Chem
. 2019 May;
294(24):9461-9475.
PMID: 31073029
The retinoid cycle is a metabolic process in the vertebrate retina that continuously regenerates 11--retinal (11-RAL) from the all--retinal (atRAL) isomer. atRAL accumulation can cause photoreceptor degeneration and irreversible visual...
8.
Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, et al.
J Pharmacol Exp Ther
. 2017 Nov;
364(2):207-220.
PMID: 29162627
Degeneration of retinal photoreceptor cells can arise from environmental and/or genetic causes. Since photoreceptor cells, the retinal pigment epithelium (RPE), neurons, and glial cells of the retina are intimately associated,...
9.
Getter T, Zaks I, Barhum Y, Ben-Zur T, Boselt S, Gregoire S, et al.
ChemMedChem
. 2015 Mar;
10(5):850-61.
PMID: 25772747
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective death of motor neurons and skeletal muscle atrophy. The majority of ALS cases are acquired spontaneously, with...
10.
Zaks I, Getter T, Gruzman A
Future Med Chem
. 2014 Aug;
6(11):1325-53.
PMID: 25163002
Recent discoveries of AMPK activators point to the large number of therapeutic candidates that can be transformed to successful designs of novel drugs. AMPK is a universal energy sensor and...