Takeshi Hirayama
Overview
Explore the profile of Takeshi Hirayama including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
423
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Recent Articles
1.
Ueda H, Honda A, Miyazaki T, Morishita Y, Hirayama T, Iwamoto J, et al.
Hepatol Commun
. 2024 Dec;
9(1).
PMID: 39670881
Background: Wild-type (WT) mice fed a conventional high-fat/high-sucrose diet (HFHSD) rarely develop metabolic dysfunction-associated steatohepatitis (MASH) with HCC. Because mouse bile acid (BA) is highly hydrophilic, we hypothesized that making...
2.
Monma T, Iwamoto J, Ueda H, Tamamushi M, Kakizaki F, Konishi N, et al.
World J Clin Cases
. 2022 Dec;
10(34):12484-12493.
PMID: 36579096
Dysbiosis in the intestinal microflora can affect the gut production of microbial metabolites, and toxic substances can disrupt the barrier function of the intestinal wall, leading to the development of...
3.
Ueda H, Honda A, Miyazaki T, Morishita Y, Hirayama T, Iwamoto J, et al.
PLoS One
. 2022 Jul;
17(7):e0271308.
PMID: 35819971
Cyp2a12-/-Cyp2c70-/- double knockout (DKO) mice have a human-like hydrophobic bile acid (BA) composition and show reduced fertility and liver injury. Ursodeoxycholic acid (UDCA) is a hydrophilic and cytoprotective BA used...
4.
Iwamoto J, Honda A, Miyazaki T, Monma T, Ueda H, Morishita Y, et al.
Hepatol Commun
. 2021 Sep;
5(12):2052-2067.
PMID: 34558859
Western-style high-fat/high-sucrose diet (HFHSD) changes gut microbiota and bile acid (BA) profiles. Because gut microbiota and BAs could influence each other, the mechanism of changes in both by HFHSD is...
5.
Kawano C, Isozaki Y, Nakagawa A, Hirayama T, Nishiyama K, Kuroyama M
Yakugaku Zasshi
. 2020 Jul;
140(7):923-928.
PMID: 32612057
Riluzole, a drug used in the management of amyotrophic lateral sclerosis (ALS), is associated with a high incidence of liver failure. It is imperative to determine risk factors and severity...
6.
Iwamoto J, Murakami M, Monma T, Ueda H, Tamamushi M, Konishi N, et al.
J Clin Biochem Nutr
. 2020 Apr;
66(2):158-162.
PMID: 32231413
Non-steroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin (LDA) are the most common causes of drug-induced gastroduodenal ulcer and We investigated preventive treatment with use of concomitant anti-ulcer drugs and the...
7.
Honda A, Miyazaki T, Iwamoto J, Hirayama T, Morishita Y, Monma T, et al.
J Lipid Res
. 2019 Oct;
61(1):54-69.
PMID: 31645370
The bile acid (BA) composition in mice is substantially different from that in humans. Chenodeoxycholic acid (CDCA) is an end product in the human liver; however, mouse metabolizes CDCA to...
8.
Murakami M, Iwamoto J, Honda A, Tsuji T, Tamamushi M, Ueda H, et al.
Inflamm Bowel Dis
. 2018 Apr;
24(5):1035-1044.
PMID: 29688473
Background: Dysbiosis, especially a reduced Clostridium subcluster XIVa (XIVa), has been reported in several gastrointestinal diseases. Since XIVa is thought to be the main bacterial cluster that metabolizes bile acids...
9.
Hirayama T, Ikegami T, Honda A, Miyazaki T, Yara S, Kohjima M, et al.
Intern Med
. 2017 Dec;
57(9):1219-1227.
PMID: 29279486
Objective Since the majority of direct-acting antivirals (DAAs) that are used in the treatment of hepatitis C virus (HCV) infection are mainly metabolized by CYP3A4, it is hypothesized that inter-individual...
10.
Iwamoto J, Murakami M, Konishi N, Monma T, Ueda H, Yara S, et al.
Intern Med
. 2017 Nov;
57(3):339-342.
PMID: 29093413
A 66-year-old Japanese male with a history of Behçet disease exhibited oral and genital ulcers, and a round deep ileocecal ulcer. He was treated with a combination of mesalazine and...