Takehito Isobe
Overview
Explore the profile of Takehito Isobe including associated specialties, affiliations and a list of published articles.
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10
Citations
73
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Recent Articles
1.
Onishi S, Nakagawa M, Matsuo S, Shinozuka J, Hiramatsu M, Isobe T, et al.
J Toxicol Pathol
. 2022 Feb;
35(1):103-106.
PMID: 35221502
Pemphigus is an autoimmune blistering disease characterized by lesions on the skin and mucous membranes. To date, no spontaneous cases of this disease have been reported in cynomolgus monkeys. This...
2.
Isobe T, Honda M, Komatsu R, Tabo M
J Toxicol Sci
. 2019 Dec;
44(12):859-870.
PMID: 31813905
We validated a motion field imaging (MFI) assay with human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) as a model to assess multiple cardiac liabilities by comparing the guinea-pig Langendorff heart...
3.
Isobe T, Honda M, Komatsu R, Tabo M
J Toxicol Sci
. 2018 Aug;
43(8):493-506.
PMID: 30078835
We used motion field imaging to characterize the conduction and contraction of a sheet of cardiomyocytes derived from human induced pluripotent stem cells (hiPS-CMs). A hiPS-CMs sheet of 2.8 mm...
4.
Ebiike H, Taka N, Matsushita M, Ohmori M, Takami K, Hyohdoh I, et al.
J Med Chem
. 2016 Dec;
59(23):10586-10600.
PMID: 27933954
The fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases regulates multiple biological processes, such as cell proliferation, migration, apoptosis, and differentiation. Various genetic alterations that drive activation of...
5.
Nakanishi Y, Akiyama N, Tsukaguchi T, Fujii T, Sakata K, Sase H, et al.
Mol Cancer Ther
. 2014 Aug;
13(11):2547-58.
PMID: 25169980
The FGF receptors (FGFR) are tyrosine kinases that are constitutively activated in a subset of tumors by genetic alterations such as gene amplifications, point mutations, or chromosomal translocations/rearrangements. Recently, small-molecule...
6.
Isobe T, Komatsu R, Honda M, Kuramoto S, Shindoh H, Tabo M
J Toxicol Sci
. 2014 Mar;
39(2):237-42.
PMID: 24646704
Anti-angiogenic drugs that target Vascular Endothelial Growth Factor (VEGF) signaling pathways caused hypertension as an adverse effect in clinical studies. Since the hypertension may limit the benefit provided for patients,...
7.
Honda M, Komatsu R, Isobe T, Tabo M, Ishikawa T
J Pharmacol Sci
. 2013 Feb;
121(2):131-7.
PMID: 23363785
Our previous study has shown that the corrected QT (QTc) interval of the electrocardiogram is longer during the dark period than during the light period in telemetered common marmosets. In...
8.
Tabo M, Komatsu R, Isobe T, Honda M, Yamada Y, Kimura K
J Toxicol Sci
. 2010 Oct;
35(5):687-98.
PMID: 20930463
The aims of this study were to determine a suitable method to correct the ventricular repolarization period against the RR interval in isolated perfused Langendorff guinea pig heart and to...
9.
Komatsu R, Honda M, Holzgrefe H, Kubo J, Yamada Y, Isobe T, et al.
J Pharmacol Toxicol Methods
. 2010 Jan;
61(3):271-6.
PMID: 20097298
Introduction: Moxifloxacin is the most widely used positive reference agent in clinical cardiac repolarization studies, but it has not been characterized in common marmosets which are uniquely suited to studies...
10.
Honda M, Komatsu R, Holzgrefe H, Yamada Y, Isobe T, Kimura K, et al.
J Pharmacol Toxicol Methods
. 2010 Jan;
61(3):264-70.
PMID: 20097297
Introduction: QT intervals are strongly influenced by preceeding heart rate history and are also characterized by rate-independent variability, leading to difficulty in precise rate-correction of the raw QT interval. The...