Takehiro Mukae
Overview
Explore the profile of Takehiro Mukae including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
118
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Recent Articles
1.
Mukae T, Yoshii K, Oishi I
Biol Pharm Bull
. 2024 Sep;
47(9):1532-1541.
PMID: 39313389
Transgenic chicken bioreactors can efficiently produce egg whites containing large quantities of recombinant proteins. We previously developed transgenic chickens that produce recombinant monoclonal antibodies (mAbs) against epidermal growth factor receptor...
2.
Nakayama Y, Masuda Y, Mukae T, Mikami T, Shimizu R, Kondo N, et al.
Commun Biol
. 2024 Jan;
7(1):129.
PMID: 38272969
Neudesin, originally identified as a neurotrophic factor, has primarily been studied for its neural functions despite its widespread expression. Using 8-week-old neudesin knockout mice, we elucidated the role of neudesin...
3.
Mukae T, Yoshii K, Watanobe T, Tagami T, Oishi I
Poult Sci
. 2021 Feb;
100(2):452-460.
PMID: 33518096
Ovomucoid is a major egg white protein which is considered as the most dominant allergen in chicken eggs. Owing to the difficulty of separating ovomucoid from egg whites, researchers have...
4.
Mukae T, Okumura S, Watanobe T, Yoshii K, Tagami T, Oishi I
Genes (Basel)
. 2021 Jan;
12(1).
PMID: 33396657
Increased commercial demand for monoclonal antibodies (mAbs) has resulted in the urgent need to establish efficient production systems. We previously developed a transgenic chicken bioreactor system that effectively produced human...
5.
Masuda Y, Nakayama Y, Mukae T, Tanaka A, Naito K, Konishi M
Int Immunopharmacol
. 2018 Dec;
67:408-416.
PMID: 30586664
Dendritic cells (DCs) play a primary role in antigen presentation to CD4 and CD8 T cells and induce acquired immune response against cancer cells. Therefore, determining positive modulators of DC...
6.
Mukae T, Fujita W, Ueda H
J Pharmacol Sci
. 2016 Feb;
131(1):64-7.
PMID: 26883455
Pregabalin (PGB) is a valuable therapeutic drug against chronic pain. Here we attempted to perform the combinatorial drug therapy with P-glycoprotein (P-gp) inhibitors to lower therapeutic dosage of PGB in...
7.
Uchida H, Matsushita Y, Araki K, Mukae T, Ueda H
J Pharmacol Sci
. 2015 Aug;
128(4):208-11.
PMID: 26318673
Neuropathic pain is often insensitive to morphine. Our previous study has demonstrated that neuron-restrictive silencer factor represses mu opioid receptor (MOP) gene expression in the dorsal root ganglion (DRG) via...
8.
Mukae T, Uchida H, Ueda H
J Pharmacol Exp Ther
. 2015 Mar;
353(3):471-9.
PMID: 25805256
Treatment of fibromyalgia is an unmet medical need. To develop novel therapies for the treatment of fibromyalgia, we explored pain therapeutic actions of existing pharmaceuticals, which inhibit the somatic symptoms...
9.
Matsushita Y, Araki K, Omotuyi O, Mukae T, Ueda H
Br J Pharmacol
. 2013 Sep;
170(5):991-8.
PMID: 24032674
Background And Purpose: Hypoesthesia is a clinical feature of neuropathic pain. The feature is partly explained by the evidence of epigenetic repression of Nav 1.8 sodium channel in the dorsal...
10.
Matsushita Y, Omotuyi I, Mukae T, Ueda H
Curr Pharm Des
. 2013 Mar;
19(42):7355-61.
PMID: 23448475
Herein, we investigated the role of periaqueductal gray (PAG)-resident microglia in the development of morphine tolerance and its underlying mechanisms. We showed that clodronate and minocycline known as microglia inhibitors...