Takashi Yokochi
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Explore the profile of Takashi Yokochi including associated specialties, affiliations and a list of published articles.
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134
Citations
1344
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Recent Articles
11.
Sidthipong K, Ma J, Yu W, Wang Y, Kobayashi S, Kishino S, et al.
Bioorg Med Chem Lett
. 2016 Dec;
27(3):562-566.
PMID: 28003138
(-)-Dehydroxymethylepoxyquinomicin ((-)-DHMEQ, 1) is a specific inhibitor of NF-κB. It binds to SH group in the specific cysteine residue of NF-κB components with its epoxide moiety to inhibit DNA binding....
12.
Yu Z, Saito H, Otsuka H, Shikama Y, Funayama H, Sakai M, et al.
Int Immunopharmacol
. 2016 Dec;
43:40-52.
PMID: 27939824
Intravenously injected lipopolysaccharides (LPS) rapidly induce pulmonary platelet accumulation (PPA) and anaphylaxis-like shock (ALS) in mice. Macrophages reportedly release catecholamines rapidly upon stimulation with LPS. Here, we examined the involvement...
13.
Suwa M, Imoto T, Kida A, Yokochi T
J Phys Ther Sci
. 2016 Jun;
28(5):1472-7.
PMID: 27313353
[Purpose] To compare the toe flexor, hand grip and knee extensor strengths of young and elderly men, and to examine the association between toe flexor strength and physical activity or...
14.
Ando T, Komatsu T, Naiki Y, Takahashi K, Yokochi T, Watanabe D, et al.
Immunopharmacol Immunotoxicol
. 2016 Jun;
38(4):298-302.
PMID: 27251848
IL-1β is one of the inflammatory cytokines and is cleaved from pro-IL-1β proteolytically by activated Caspase 1. For the activation of Caspase 1, inflammasome was formed by two signals, what...
15.
Ando T, Komatsu T, Naiki Y, Yokochi T, Watanabe D, Koide N
Biomed Pharmacother
. 2015 Dec;
76:1-5.
PMID: 26653542
It has been known that LPS activates macrophages and induces IFN-β production from macrophages. The endogenous IFN-β produced by LPS stimulates the cells, which plays a role in innate immune....
16.
Naiki Y, Komatsu T, Koide N, Dagvadorj J, Yoshida T, Arditi M, et al.
Innate Immun
. 2015 Jul;
21(7):770-7.
PMID: 26224488
The effect of TGF-β1 on CpG DNA-induced type I IFN production was examined by reconstituting a series of signaling molecules in TLR 3 signaling. TGF-β1 inhibited CpG DNA-induced IFN-α4 productivity...
17.
Kato Y, Kamiya H, Koide N, Odkhuu E, Komatsu T, Watarai A, et al.
Int Immunopharmacol
. 2015 Mar;
26(1):97-102.
PMID: 25817178
High-mobility group box 1 (HMGB1) is suggested to participate in development of local and systemic inflammatory disorders. Irbesartan (IRB), an angiotensin II type1 receptor blocker, is widely used for treatment...
18.
Koide N, Kaneda A, Yokochi T, Umezawa K
Int Immunopharmacol
. 2015 Jan;
25(1):162-8.
PMID: 25617668
We have isolated 9-methylstreptimidone from microorganism as a new NF-κB inhibitor. Later, we designed 3-[(dodecylthiocarbonyl) methyl]-glutarimide (DTCM-glutarimide) as an analog of this compound, which shows anti-inflammatory activity in vivo. In...
19.
Mori D, Koide N, Tsolmongyn B, Nagata H, Sano T, Nonami T, et al.
Microvasc Res
. 2015 Jan;
98:68-73.
PMID: 25582076
The effect of poly I:C on interferon (IFN)-γ-induced nitric oxide (NO) production in vascular endothelial cells was examined using murine aortic endothelial END-D cells. Poly I:C augmented IFN-γ-induced NO production...
20.
Odkhuu E, Komatsu T, Naiki Y, Koide N, Yokochi T
Int Immunopharmacol
. 2014 Sep;
23(1):267-72.
PMID: 25242386
The effect of Sendai virus (SeV) C protein on lipopolysaccharide (LPS)-induced nitric oxide (NO) production was examined using RAW 264.7 macrophage cells. Infection of SeV inhibited LPS-induced NO production via...