Takashi Okauchi
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Explore the profile of Takashi Okauchi including associated specialties, affiliations and a list of published articles.
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Articles
52
Citations
803
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Recent Articles
1.
Kida T, Takahashi N, Mori M, Sun J, Oota H, Nishino K, et al.
RSC Med Chem
. 2022 Nov;
13(10):1197-1204.
PMID: 36325399
Transient receptor potential cation channel subfamily V member 1 (TRPV1)-targeted compounds were synthesized by modifying the structure of SB366791, a pharmaceutically representative TRPV1 antagonist. To avoid amide-iminol tautomerization, structurally supported...
2.
Mimura K, Nagai Y, Inoue K, Matsumoto J, Hori Y, Sato C, et al.
iScience
. 2021 Sep;
24(9):103066.
PMID: 34568790
To interrogate particular neuronal pathways in nonhuman primates under natural and stress-free conditions, we applied designer receptors exclusively activated by designer drugs (DREADDs) technology to common marmosets. We injected adeno-associated...
3.
Hu D, Li D, Shigeta M, Ochi Y, Okauchi T, Neyama H, et al.
Biochem Biophys Res Commun
. 2020 Dec;
535:1-5.
PMID: 33340760
Reactive oxygen species (ROS) are highly reactive and directly attack surrounding biomolecules to deteriorate cellular and tissue functions. Meanwhile, ROS also serve as signaling mediators to upregulate pro-inflammatory cytokine expression...
4.
Huang T, Okauchi T, Hu D, Shigeta M, Wu Y, Wada Y, et al.
Mol Pain
. 2019 Nov;
15:1744806919891327.
PMID: 31709891
No abstract available.
5.
Fuchigami T, Fujimoto N, Haradahira T, Nojiri Y, Okauchi T, Maeda J, et al.
J Labelled Comp Radiopharm
. 2018 Oct;
61(14):1095-1105.
PMID: 30375667
GluN2B-containing NMDA receptors (NMDARs) play fundamental roles in learning and memory, although they are also associated with various brain disorders. In this study, we synthesized and evaluated three C-labeled N-benzyl...
6.
Fukuchi T, Okauchi T, Shigeta M, Yamamoto S, Watanabe Y, Enomoto S
Med Phys
. 2017 Feb;
44(6):2257-2266.
PMID: 28168704
Purpose: Positron emission tomography (PET) is a useful imaging modality that quantifies the physiological distributions of radiolabeled tracers in vivo in humans and animals. However, this technique is unsuitable for...
7.
Shingaki T, Katayama Y, Nakaoka T, Takashima T, Onoe K, Okauchi T, et al.
Pharm Res
. 2016 Feb;
33(5):1235-48.
PMID: 26869173
Purpose: To select appropriate antiemetics relieving teriparatide-induced nausea and vomiting during osteoporosis treatment using PET molecular imaging and pharmacokinetic analysis. Methods: Rats were pretreated with subcutaneous teriparatide, followed by oral...
8.
Kanzaki A, Okauchi T, Hu D, Shingaki T, Katayama Y, Koyama H, et al.
J Neurosci Res
. 2016 Feb;
94(5):424-9.
PMID: 26864568
Homeostasis is known to be involved in maintaining the optimal internal environment, helping to achieve the best performance of biological functions. At the same time, a deviation from optimal conditions...
9.
Shingaki T, Katayama Y, Nakaoka T, Irie S, Onoe K, Okauchi T, et al.
Eur J Pharm Biopharm
. 2015 Dec;
99:45-53.
PMID: 26639201
We performed positron emission tomography (PET) using 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) to evaluate the pharmacokinetics of nasal drug absorption in the rat. The dosing solution of [(18)F]FDG was varied in volume (ranging...
10.
Shingaki T, Hume W, Takashima T, Katayama Y, Okauchi T, Hayashinaka E, et al.
Pharm Res
. 2015 Feb;
32(8):2538-47.
PMID: 25715695
Purpose: To evaluate the function of multidrug and toxin extrusion proteins (MATEs) using (11)C-labeled metformin ([(11)C]metformin) by positron emission tomography (PET). Methods: PET was performed by intravenous bolus injection of...