Takashi Hirasawa
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Explore the profile of Takashi Hirasawa including associated specialties, affiliations and a list of published articles.
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65
Citations
1171
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Recent Articles
1.
Matsuhisa K, Ogawa K, Komata K, Hirasawa T
Appl Microbiol Biotechnol
. 2025 Mar;
109(1):61.
PMID: 40063103
Cysteine, a common amino acid used in food, cosmetic, and pharmaceutical industries, has a growth inhibitory effect. This growth inhibition by cysteine poses a problem, as the production of cysteine...
2.
Hirasawa T, Satoh Y, Koma D
World J Microbiol Biotechnol
. 2025 Feb;
41(2):65.
PMID: 39915353
Demand for aromatic amino acids (AAAs), such as L-phenylalanine, L-tyrosine, and L-tryptophan, has been increasing as they are used in animal feed and as precursors in the synthesis of industrial...
3.
Ochiai T, Wachi M, Hirasawa T
Microbiology (Reading)
. 2024 Oct;
170(10).
PMID: 39373177
The study investigates the effect of biotin concentration on the role of anaplerotic reactions catalysed by pyruvate carboxylase (PC) and phosphoenolpyruvate carboxylase (PEPC) in glutamic acid production by requires biotin...
4.
Tachikawa Y, Okuno M, Itoh T, Hirasawa T
J Biosci Bioeng
. 2024 Feb;
137(5):344-353.
PMID: 38365536
The mutants resistant to a phenylalanine analog, 4-fluorophenylalanine (4FP), were obtained for metabolic engineering of Corynebacterium glutamicum for producing aromatic amino acids synthesized through the shikimate pathway by adaptive laboratory...
5.
Sone M, Navanopparatsakul K, Takahashi S, Furusawa C, Hirasawa T
World J Microbiol Biotechnol
. 2023 Jul;
39(10):255.
PMID: 37474876
We previously isolated a mutant of Saccharomyces cerevisiae strain 85_9 whose glycerol assimilation was improved through adaptive laboratory evolution. To investigate the mechanism for this improved glycerol assimilation, genome resequencing...
6.
Hirasawa T, Maeda T
Microorganisms
. 2023 Jan;
11(1).
PMID: 36677384
Adaptive laboratory evolution (ALE) is a useful experimental methodology for fundamental scientific research and industrial applications to create microbial cell factories. By using ALE, cells are adapted to the environment...
7.
Hirasawa T, Shimoyamada Y, Tachikawa Y, Satoh Y, Kawano Y, Dairi T, et al.
J Biosci Bioeng
. 2022 Nov;
135(1):25-33.
PMID: 36334975
In this study, Corynebacterium glutamicum was engineered to produce ergothioneine, an amino acid derivative with high antioxidant activity. The ergothioneine biosynthesis genes, egtABCDE, from Mycolicibacterium smegmatis were introduced into wild-type...
8.
Yamamoto J, Chumsakul O, Toya Y, Morimoto T, Liu S, Masuda K, et al.
DNA Res
. 2022 May;
29(3).
PMID: 35608323
Partial bacterial genome reduction by genome engineering can improve the productivity of various metabolites, possibly via deletion of non-essential genome regions involved in undesirable metabolic pathways competing with pathways for...
9.
Grinanda D, Hirasawa T
Biosci Biotechnol Biochem
. 2022 Feb;
86(4):543-551.
PMID: 35102407
We investigated the performance of a genome-reduced strain of Bacillus subtilis MGB874, whose 0.87 Mbp of genomic DNA was cumulatively deleted, as an ethanol production host. A recombinant strain A267_EtOH...
10.
Ogata S, Hirasawa T
Appl Microbiol Biotechnol
. 2021 Aug;
105(18):6909-6920.
PMID: 34463802
From the previous transcriptome analysis (Hirasawa et al. Biotechnol J 13:e1700612, 2018), it was found that expression of genes whose expression is regulated by stress-responsive transcriptional regulators was altered during...