Takamitsu Hosoya
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Explore the profile of Takamitsu Hosoya including associated specialties, affiliations and a list of published articles.
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162
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1555
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Recent Articles
11.
Sakata Y, Nabekura R, Hazama Y, Hanya M, Nishiyama T, Kii I, et al.
Org Lett
. 2022 Dec;
25(7):1051-1055.
PMID: 36511709
A concise route for dibenzoazacyclooctynes (DIBACs) synthesis was developed based on Pictet-Spengler reaction and a novel cobalt decomplexation method established for dibenzo-fused cyclooctyne-cobalt complexes. The method allowed for the facile...
12.
Katayama A, Jin Y, Nishiyama Y, Hosoya T, Yokoshima S
Org Lett
. 2022 Sep;
24(40):7361-7365.
PMID: 36178802
Upon treatment of α-azido sulfones with a thiol in the presence of 1,1,3,3-tetramethylguanidine, substitution of the sulfonyl group with a thiolate occurred, resulting in the formation of α-azido sulfides. Based...
13.
Inouye S, Sato J, Sahara-Miura Y, Tomabechi Y, Sumida Y, Sekine S, et al.
PLoS One
. 2022 Sep;
17(9):e0272992.
PMID: 36129943
Native Oplophorus luciferase (OpLase) and its catalytic 19 kDa protein (wild KAZ) show highest luminescence activity with coelenterazine (CTZ) among CTZ analogs. Mutated wild KAZ with 16 amino acid substitutions...
14.
Yoshida S, Kuribara T, Morita T, Matsuzawa T, Morimoto K, Kobayashi T, et al.
RSC Adv
. 2022 May;
8(39):21754-21758.
PMID: 35541723
Various 2,3-disubstituted 6,7-thienobenzynes have been efficiently generated from the corresponding -silylaryl triflate-type precursors by activation with fluoride ions. The method has expanded the scope of synthesizable multisubstituted benzothiophenes, including those...
15.
Sugiyama K, Sakata Y, Niwa T, Yoshida S, Hosoya T
Chem Commun (Camb)
. 2022 May;
58(42):6235-6238.
PMID: 35510642
The iridium-catalyzed azide-thioalkyne cycloaddition was found to proceed much faster with benzyl azide than with phenyl azide. The high azido-type selectivity was also observed in other combinations of azides with...
16.
Nakaoka T, Kaneko K, Irie S, Mawatari A, Igesaka A, Uetake Y, et al.
Drug Metab Pharmacokinet
. 2022 Apr;
44:100449.
PMID: 35395593
It is widely accepted that uptake and efflux transporters on clearance organs play crucial roles in drug disposition. Although in vitro transporter assay system can identify the intrinsic properties of...
17.
Kimura N, Saito K, Niwa T, Yamakawa M, Igaue S, Ohkanda J, et al.
Protein Expr Purif
. 2022 Mar;
195-196:106089.
PMID: 35307559
The kinase DYRK1A phosphorylates substrate proteins that are involved in the progression of many diseases. DYRK1A also phosphorylates its own residues on key elements intramolecularly to activate and stabilize itself...
18.
Takemura H, Orimoto G, Kobayashi A, Hosoya T, Yoshida S
Org Biomol Chem
. 2022 Feb;
20(30):6007-6011.
PMID: 35201255
Assembling methods using 2-azidoacrylamides having a nucleophilic amino group are disclosed. Divergent transformations of the amine-type trivalent platform were accomplished with a wide variety of electrophiles to obtain a broad...
19.
Idogawa R, Kobayashi A, Kim Y, Shimomori K, Hosoya T, Yoshida S
Chem Commun (Camb)
. 2022 Feb;
58(21):3521-3524.
PMID: 35195117
An efficient method for sequential C-F transformations of -hydrosilyl-substituted benzotrifluorides is disclosed. A key to the success is hydride reduction of -fluorosilyl-substituted difluoromethylenes prepared by a single C-F transformation of...
20.
Inouye S, Nakamura M, Hosoya T
Photochem Photobiol
. 2021 Dec;
98(5):1068-1076.
PMID: 34971002
Aequorin consists of apoprotein (apoAequorin) and (S)-2-peroxycoelenterazine (CTZ-OOH) and is considered to be a transient-state complex of an enzyme (apoAequorin) and a substrate (coelenterazine and molecular oxygen) in the enzymatic...