Taciani de Almeida Magalhaes
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Explore the profile of Taciani de Almeida Magalhaes including associated specialties, affiliations and a list of published articles.
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14
Citations
87
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Recent Articles
1.
Chen A, Lupan A, Quek R, Stanciu S, Asaftei M, Stanciu G, et al.
Sci Adv
. 2024 Nov;
10(45):eadq9580.
PMID: 39514670
Coronavirus-infected cells contain double-membrane vesicles (DMVs) that are key for viral RNA replication and transcription, perforated by hexameric pores connecting the vesicular lumen to the cytoplasm. How pores form and...
2.
Borges K, Little 3rd D, de Almeida Magalhaes T, Ribeiro C, Dumontet T, Lapensee C, et al.
bioRxiv
. 2024 Sep;
PMID: 39229119
The steroid hormone aldosterone, produced by the zona glomerulosa (zG) of the adrenal gland, is a master regulator of plasma electrolytes and blood pressure. While aldosterone control by the renin-angiotensin...
3.
de Almeida Magalhaes T, Liu J, Chan C, Borges K, Zhang J, Kane A, et al.
Dev Cell
. 2023 Dec;
59(2):244-261.e6.
PMID: 38154460
WNT morphogens trigger signaling pathways fundamental for embryogenesis, regeneration, and cancer. WNTs are modified with palmitoleate, which is critical for binding Frizzled (FZD) receptors and activating signaling. However, it is...
4.
Quek R, Hardy K, Walker S, Nguyen D, de Almeida Magalhaes T, Salic A, et al.
ACS Chem Biol
. 2023 Feb;
18(3):583-594.
PMID: 36795767
Biomolecular condensates formed by liquid-liquid phase separation have been implicated in multiple diseases. Modulation of condensate dynamics by small molecules has therapeutic potential, but so far, few condensate modulators have...
5.
de Almeida Magalhaes T, Cruzeiro G, de Sousa G, Englinger B, Nagano L, Ancliffe M, et al.
Neuro Oncol
. 2022 May;
25(1):185-198.
PMID: 35640920
Background: Supratentorial RELA fusion (ST-RELA) ependymomas (EPNs) are resistant tumors without an approved chemotherapeutic treatment. Unfortunately, the molecular mechanisms that lead to chemoresistance traits of ST-RELA remain elusive. The aim...
6.
Cruzeiro G, de Almeida Magalhaes T, de Sousa G, Bonfim Silva R, de Biagi Junior C, das Chagas P, et al.
Cancers (Basel)
. 2021 Dec;
13(24).
PMID: 34944872
Advances in genomics have led to the identification of twelve relevant molecular subtypes within medulloblastoma (MB). The alpha subtype of Sonic hedgehog-driven MB is resistant to therapy (including smoothened inhibitors)...
7.
de Sousa G, Lira R, de Almeida Magalhaes T, da Silva K, Nagano L, Saggioro F, et al.
J Mol Med (Berl)
. 2021 Apr;
99(8):1101-1113.
PMID: 33903940
Although ependymoma (EPN) molecular subgroups have been well established by integrated high-throughput platforms, low- and middle-income countries still need low-cost techniques to promptly classify these molecular subtypes. Here, we applied...
8.
Petrov K, de Almeida Magalhaes T, Salic A
Proc Natl Acad Sci U S A
. 2021 Feb;
118(6).
PMID: 33526656
Hedgehog signaling is fundamental in animal embryogenesis, and its dysregulation causes cancer and birth defects. The pathway is triggered when the Hedgehog ligand inhibits the Patched1 membrane receptor, relieving repression...
9.
de Almeida Magalhaes T, de Sousa G, Cruzeiro G, Tone L, Valera E, Borges K
J Mol Med (Berl)
. 2020 Mar;
98(4):495-512.
PMID: 32219470
Glioblastoma is the most common aggressive primary brain tumor. Standard care includes maximal safe surgical resection, radiation, and chemotherapy with temozolomide. However, the impact of this therapeutic approach on patient...
10.
de Almeida Magalhaes T, Borges K, de Sousa G, Brandalise S, Seidinger A, Scrideli C, et al.
Neurol Sci
. 2019 Nov;
41(3):691-694.
PMID: 31728854
Background: Ependymoma (EPN) is the third most common childhood cancer of the central nervous system. RELA fusion-positive EPN accounts for approximately 70% of all childhood supratentorial tumors and shows the...