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Tabitha A Harrison

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Articles 95
Citations 2881
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Recent Articles
21.
Su Y, Sakoda L, Jeon J, Thomas M, Lin Y, Schneider J, et al.
Cancer Epidemiol Biomarkers Prev . 2023 Jan; 32(3):353-362. PMID: 36622766
Background: Polygenic risk scores (PRS) which summarize individuals' genetic risk profile may enhance targeted colorectal cancer screening. A critical step towards clinical implementation is rigorous external validations in large community-based...
22.
Carreras-Torres R, Kim A, Lin Y, Diez-Obrero V, Bien S, Qu C, et al.
Cancer Epidemiol Biomarkers Prev . 2022 Dec; 32(3):315-328. PMID: 36576985
Background: Tobacco smoking is an established risk factor for colorectal cancer. However, genetically defined population subgroups may have increased susceptibility to smoking-related effects on colorectal cancer. Methods: A genome-wide interaction...
23.
Murphy N, Newton C, Song M, Papadimitriou N, Hoffmeister M, Phipps A, et al.
J Natl Cancer Inst . 2022 Nov; 115(2):165-173. PMID: 36445035
Background: Obesity is an established risk factor for colorectal cancer (CRC), but the evidence for the association is inconsistent across molecular subtypes of the disease. Methods: We pooled data on...
24.
Yin H, Harrison T, Thomas S, Sather C, Koehne A, Malen R, et al.
Cancer Med . 2022 Nov; 12(6):6583-6593. PMID: 36341526
Background: The anti-tumor immune response plays a key role in colorectal cancer (CRC) progression and survival. The T cell-inflamed gene expression profile (GEP) is a biomarker predicting response to checkpoint...
25.
Park H, Edelmann D, Canzian F, Harrison T, Hua X, Shi Q, et al.
Cancer Epidemiol Biomarkers Prev . 2022 Aug; 31(11):2087-2091. PMID: 35984985
Background: Associations between candidate germline genetic variants and treatment outcome of oxaliplatin, a drug commonly used for patients with colorectal cancer, have been reported but not robustly established. This study...
26.
Barfield R, Qu C, Steinfelder R, Zeng C, Harrison T, Brezina S, et al.
Sci Rep . 2022 Jun; 12(1):10207. PMID: 35715570
Colorectal cancer (CRC) is a heterogeneous disease with evidence of distinct tumor types that develop through different somatically altered pathways. To better understand the impact of the host genome on...
27.
Georgeson P, Harrison T, Pope B, Zaidi S, Qu C, Steinfelder R, et al.
Nat Commun . 2022 Jun; 13(1):3254. PMID: 35668106
Carriers of germline biallelic pathogenic variants in the MUTYH gene have a high risk of colorectal cancer. We test 5649 colorectal cancers to evaluate the discriminatory potential of a tumor...
28.
Tian Y, Kim A, Bien S, Lin Y, Qu C, Harrison T, et al.
J Natl Cancer Inst . 2022 May; 114(8):1135-1148. PMID: 35512400
Background: The use of menopausal hormone therapy (MHT) may interact with genetic variants to influence colorectal cancer (CRC) risk. Methods: We conducted a genome-wide, gene-environment interaction between single nucleotide polymorphisms...
29.
Jordahl K, Shcherbina A, Kim A, Su Y, Lin Y, Wang J, et al.
Cancer Epidemiol Biomarkers Prev . 2022 Apr; 31(5):1077-1089. PMID: 35438744
Background: Currently known associations between common genetic variants and colorectal cancer explain less than half of its heritability of 25%. As alcohol consumption has a J-shape association with colorectal cancer...
30.
Barfield R, Huyghe J, Lemire M, Dong X, Su Y, Brezina S, et al.
Cancer Epidemiol Biomarkers Prev . 2022 Mar; 31(5):1068-1076. PMID: 35247911
Background: Colorectal cancer has a strong epigenetic component that is accompanied by frequent DNA methylation (DNAm) alterations in addition to heritable genetic risk. It is of interest to understand the...