T Roderick Docking
Overview
Explore the profile of T Roderick Docking including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
1048
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0
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Recent Articles
1.
Akhade V, Liu T, Docking T, Jiang J, Gopal A, Karsan A
Leukemia
. 2023 Feb;
37(4):776-787.
PMID: 36788336
We recently described a 16-gene expression signature for improved risk stratification of acute myeloid leukemia (AML) patients called the AML Prognostic Score (APS). A subset of APS-high-risk AML patients showed...
2.
Docking T, Parker J, Jadersten M, Duns G, Chang L, Jiang J, et al.
Nat Commun
. 2021 May;
12(1):2474.
PMID: 33931648
As more clinically-relevant genomic features of myeloid malignancies are revealed, it has become clear that targeted clinical genetic testing is inadequate for risk stratification. Here, we develop and validate a...
3.
Starks E, Swanson L, Docking T, Bosdet I, Munro S, Moore R, et al.
J Mol Diagn
. 2021 Jan;
23(4):455-466.
PMID: 33486075
Clinical reporting of solid tumor sequencing requires reliable assessment of the accuracy and reproducibility of each assay. Somatic mutation variant allele fractions may be below 10% in many samples due...
4.
Grants J, Wegrzyn J, Hui T, ONeill K, Shadbolt M, Knapp D, et al.
Blood
. 2020 May;
135(25):2235-2251.
PMID: 32384151
Aging is associated with significant changes in the hematopoietic system, including increased inflammation, impaired hematopoietic stem cell (HSC) function, and increased incidence of myeloid malignancy. Inflammation of aging ("inflammaging") has...
5.
Martinez-Hoyer S, Deng Y, Parker J, Jiang J, Mo A, Docking T, et al.
Nat Cell Biol
. 2020 Apr;
22(5):526-533.
PMID: 32251398
Interstitial deletion of the long arm of chromosome 5 (del(5q)) is the most common structural genomic variant in myelodysplastic syndromes (MDS). Lenalidomide (LEN) is the treatment of choice for patients...
6.
Moore R, Zeng T, Docking T, Bosdet I, Butterfield Y, Munro S, et al.
J Mol Diagn
. 2019 Dec;
22(2):141-146.
PMID: 31837431
Sample tracking and identity are essential when processing multiple samples in parallel. Sequencing applications often involve high sample numbers, and the data are frequently used in a clinical setting. As...
7.
Docking T, Karsan A
Int J Lab Hematol
. 2019 May;
41 Suppl 1:117-125.
PMID: 31069982
Clinical genetic testing in the myeloid malignancies is undergoing a rapid transition from the era of cytogenetics and single-gene testing to an era dominated by next-generation sequencing (NGS). This transition...
8.
Parker J, Yap S, Starks E, Slind J, Swanson L, Docking T, et al.
J Mol Diagn
. 2019 May;
21(4):705-717.
PMID: 31055024
Formalin fixation is the standard method for the preservation of tissue for diagnostic purposes, including pathologic review and molecular assays. However, this method is known to cause artifacts that can...
9.
Agrahari R, Foroushani A, Docking T, Chang L, Duns G, Hudoba M, et al.
Sci Rep
. 2018 May;
8(1):6951.
PMID: 29725024
Network analysis is the preferred approach for the detection of subtle but coordinated changes in expression of an interacting and related set of genes. We introduce a novel method based...
10.
Birol I, Raymond A, Chiu R, Nip K, Jackman S, Kreitzman M, et al.
Pac Symp Biocomput
. 2015 Jan;
:347-58.
PMID: 25592595
In eukaryotic cells, alternative cleavage of 3' untranslated regions (UTRs) can affect transcript stability, transport and translation. For polyadenylated (poly(A)) transcripts, cleavage sites can be characterized with short-read sequencing using...